6-Aryl Isoindolin-1-ones: Novel mGluR2 Negative Allosteric Modulators.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00106
Abstract: This highlight presents novel 6-aryl isoindolin-1-one derivatives that developed as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 2 (mGluR2). Chemical synthesis and potency (IC50) data for both mGluR2 and mGluR3 are disclosed. read more here.
Keywords: allosteric modulators; negative allosteric; aryl isoindolin; ones novel ... See more keywords
1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28073203
Abstract: Human health is experiencing several obstacles in the modern medical era, particularly cancer. As a result, the cancer therapeutic arsenal should be continually expanded with innovative small molecules that preferentially target tumour cells. In this… read more here.
Keywords: benzyl bromo; ones novel; bromo hydrazonoindolin; activity ... See more keywords