Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major
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DOI: 10.3324/haematol.2017.181511
Abstract: b-thalassemia is one of the most common congenital red blood cell (RBC) disorders characterized by limited bglobin synthesis and ineffective erythropoiesis. Based on the requirements for blood transfusion, the disease can be classified as non-transfusion… read more here.
Keywords: supplementary figure; figure; online supplementary; transfusion ... See more keywords
TP53 immunohistochemistry correlates with TP53 mutation status and clearance in decitabine-treated patients with myeloid malignancies
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DOI: 10.3324/haematol.2018.205302
Abstract: TP53 mutations are associated with adverse prognosis in both myelodysplastic syndromes (MDS) and in acute myeloid leukemia (AML). Clinical trials focused on therapeutic options for this group of high-risk patients require a rapid, inexpensive technique… read more here.
Keywords: tp53 mutation; figure; online supplementary; tp53 mutations ... See more keywords
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy
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DOI: 10.3324/haematol.2018.209080
Abstract: Follicular lymphoma (FL) usually follows an indolent course and responds well to initial treatment. Overall survival (OS) has improved after the introduction of rituximab, yet most patients experience multiple relapses and die from lymphoma. For… read more here.
Keywords: risk; figure; treatment; online supplementary ... See more keywords
Apoptotic mesenchymal stromal cells induce prostaglandin E2 in monocytes: implications for the monitoring of mesenchymal stromal cell activity
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DOI: 10.3324/haematol.2018.214767
Abstract: Extensive experience with mesenchymal stromal cells (MSC) in the treatment of inflammatory disorders has provided convincing evidence to support their clinical efficacy in selected cases, especially in steroid-resistant acute graft-versus-host disease (GvHD). Although MSC can… read more here.
Keywords: mesenchymal stromal; online supplementary; stromal cells; msc ... See more keywords
Genomic and outcome analysis of adult T-cell lymphoblastic lymphoma
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DOI: 10.3324/haematol.2019.220863
Abstract: T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphoid neoplasm occurring predominantly in children and young adults. T-LBL is characterized by a proliferation of T lymphoblasts arrested at an early stage of maturation and… read more here.
Keywords: lbl patients; cell lymphoblastic; supplementary figure; online supplementary ... See more keywords
Novel L-nucleoside analog, 5-fluorotroxacitabine, displays potent efficacy against acute myeloid leukemia
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DOI: 10.3324/haematol.2019.226795
Abstract: Cytarabine (Ara-C) is a nucleotide analog and a cornerstone of standard chemotherapy in acute myeloid leukemia (AML). Ara-C is phosphorylated to its active metabolite Ara-CTP where it becomes incorporated into replicating DNA strands. Ara-CTP is… read more here.
Keywords: cda; supplementary figure; figure; online supplementary ... See more keywords
Exome sequencing reveals heterogeneous clonal dynamics in donor cell myeloid neoplasms after stem cell transplantation.
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DOI: 10.3324/haematol.2019.234609
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for myeloid neoplasms (MN). In rare cases, the development of de novo hematologic malignancies derived from cells of donor origin, named donor cell hematologic… read more here.
Keywords: online supplementary; stem cell; transplantation; donor cell ... See more keywords
Epigenetic and functional changes imposed by NUP98-HOXA9 in a genetically engineered model of chronic myeloid leukemia progression.
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DOI: 10.3324/haematol.2020.249243
Abstract: NUP98-HOXA9 (“NA9”) is a fusion gene commonly found, together with other mutations, in human acute myeloid leukemia cells, and occasionally in blast-phase (BP) cells of patients with chronic myeloid leukemia (CML) in whom disease progression… read more here.
Keywords: cml; myeloid leukemia; online supplementary; nup98 hoxa9 ... See more keywords