Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound
Sign Up to like & getrecommendations! Published in 2025 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.5c00215
Abstract: Herein we describe our continuing work on the K2P family of potassium ion channels with the chemical optimization of a selective and CNS penetrant series of TREK inhibitors, culminating in the discovery of ONO-TR-772 (VU6018042).… read more here.
Keywords: selective cns; ono 772; trek; cns penetrant ... See more keywords