Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51689
Abstract: Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well… read more here.
Keywords: alzheimer disease; onset; late onset; onset alzheimer ... See more keywords
Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.537
Abstract: To identify rare causal variants underlying known loci that segregate with late‐onset Alzheimer's disease (LOAD) in multiplex families. read more here.
Keywords: late onset; whole genome; alzheimer disease; genome sequencing ... See more keywords
Integrated late onset Alzheimer's disease (LOAD) susceptibility genes: Cholesterol metabolism and trafficking perspectives.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.10.022
Abstract: Late onset Alzheimer's disease (LOAD) is the most common type of dementia and is characterized by decreased amyloid-β (Aβ) clearance from the brain. Cholesterol regulates the production and clearance of Aβ. Genome-wide association study (GWAS)… read more here.
Keywords: late onset; alzheimer disease; load susceptibility; load ... See more keywords
Identification of two pathogenic mutations in SORL1 in early-onset Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2021.05.020
Abstract: The sortilin-related receptor 1 (SORL1) gene has been the subject of many studies focusing on frequent polymorphisms, which is associated with increased risk for Alzheimer's Disease (AD). By whole-exome sequencing (WES), we identified two pathogenic… read more here.
Keywords: two pathogenic; early onset; alzheimer disease; disease ... See more keywords
Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.04.012
Abstract: In the present study, a novel mutation in exon 7 of presenilin 1 (Leu232Pro) was discovered in a Korean patient with early-onset Alzheimer's disease, who represented memory decline at 37 years of age, followed by impairment… read more here.
Keywords: early onset; psen1; patient early; onset alzheimer ... See more keywords
Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0298-8
Abstract: Categorizing people with late-onset Alzheimer’s disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people… read more here.
Keywords: late onset; cognitively defined; alzheimer disease; disease ... See more keywords
Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01531-9
Abstract: Early-onset Alzheimer’s disease (EOAD) is a rare but particularly devastating form of AD. Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same neuropathological hallmarks underlying the more common, late-onset… read more here.
Keywords: onset alzheimer; early onset; eoad; alzheimer disease ... See more keywords
Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18534-1
Abstract: Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (Poptimal) of a genetic risk… read more here.
Keywords: late onset; risk; alzheimer disease; load ... See more keywords
Critical role of mitosis in spontaneous late-onset Alzheimer’s disease; from a Shugoshin 1 cohesinopathy mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1515554
Abstract: ABSTRACT From early-onset Alzheimer’s disease (EOAD) studies, the amyloid-beta hypothesis emerged as the foremost theory of the pathological causes of AD. However, how amyloid-beta accumulation is triggered and progresses toward senile plaques in spontaneous late-onset… read more here.
Keywords: late onset; alzheimer disease; disease; load ... See more keywords
Distinct 18F‐AV‐1451 tau PET retention patterns in early‐ and late‐onset Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Brain"
DOI: 10.1093/brain/awx171
Abstract: &NA; Patients with Alzheimer's disease can present with different clinical phenotypes. Individuals with late‐onset Alzheimer's disease (>65 years) typically present with medial temporal lobe neurodegeneration and predominantly amnestic symptomatology, while patients with early‐onset Alzheimer's disease… read more here.
Keywords: late onset; alzheimer disease; disease; 18f 1451 ... See more keywords
A multimodal, longitudinal study of cognitive heterogeneity in early-onset Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of neurology"
DOI: 10.1111/ene.15097
Abstract: BACKGROUND Alzheimer's disease (AD) is a heterogeneous pathology. Young patients with AD are particularly likely to have an atypical presentation. The objectives of the present cluster analysis were to determine whether patients with early-onset Alzheimer's… read more here.
Keywords: early onset; alzheimer disease; multimodal longitudinal; alzheimer ... See more keywords