Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway
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DOI: 10.1038/s41388-018-0253-9
Abstract: The early onset breast cancer patients (age ≤ 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of… read more here.
Keywords: gas7; early onset; onset breast; breast cancer ... See more keywords
Toenail-Based Metal Concentrations and Young-Onset Breast Cancer
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DOI: 10.1093/aje/kwy283
Abstract: Several metals have carcinogenic properties, but their associations with breast cancer are not established. We studied cadmium, a metalloestrogen, and 9 other metals-arsenic, cobalt, chromium, copper, mercury, molybdenum, lead, tin, and vanadium--in relation to young-onset… read more here.
Keywords: toenail; onset breast; breast cancer; young onset ... See more keywords
Contribution of BRCA1 and BRCA2 germline mutations to early onset breast cancer: a series from north of Morocco
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DOI: 10.1186/s12885-020-07352-9
Abstract: Background To date, the contribution of BRCA1/2 mutations in Moroccan early onset breast cancer patients remains unknown. Here we assess these genetic alterations for the first time in a cohort from North of Morocco. Methods… read more here.
Keywords: contribution brca1; early onset; onset breast; breast cancer ... See more keywords
Mutational landscape differences between young-onset and older-onset breast cancer patients
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DOI: 10.1186/s12885-020-6684-z
Abstract: Background The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting… read more here.
Keywords: young onset; onset breast; older onset; breast cancer ... See more keywords
Characteristics of intestinal microbiota in infants with late-onset breast milk jaundice
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DOI: 10.3389/fnut.2023.1119768
Abstract: Introduction In this paper, microbiota analysis was determined to analyze the structure and difference of intestinal microbiota between LBMJ (late-onset breast milk jaundice) infants and healthy individuals. Methods We collected fresh fecal samples from 13… read more here.
Keywords: intestinal microbiota; microbiota; breast milk; onset breast ... See more keywords
Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer
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DOI: 10.3390/cancers11010058
Abstract: Early age at onset of breast cancer (eoBC) is suggestive of an increased genetic risk. Although genetic testing is offered to all eoBC-affected women, in isolated cases the detection rate of pathogenic variants is 60%… read more here.
Keywords: methylation; brca1; onset breast; promoter ... See more keywords