A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14561
Abstract: Glucokinase (GCK) is the pancreatic β-cell glucose sensor, and its kinetics are key to that purpose. A slow transition step, displayed as non-hyperbolic kinetics, and a low affinity for glucose characterize GCK. Mutations in GCK… read more here.
Keywords: young type; diabetes young; maturity onset; onset diabetes ... See more keywords
Adult‐onset diabetes in Middle Eastern immigrants to Sweden: Novel subgroups and diabetic complications—The All New Diabetes in Scania cohort diabetic complications and ethnicity
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3419
Abstract: Middle Eastern immigrants to Europe represent a high risk population for type 2 diabetes. We compared prevalence of novel subgroups and assessed risk of diabetic macro‐ and microvascular complications between diabetes patients of Middle Eastern… read more here.
Keywords: adult onset; novel subgroups; onset diabetes; eastern immigrants ... See more keywords
Glucose variability during the early course of acute pancreatitis predicts two‐year probability of new‐onset diabetes: A prospective longitudinal cohort study
Sign Up to like & getrecommendations! Published in 2022 at "United European Gastroenterology Journal"
DOI: 10.1002/ueg2.12190
Abstract: Abstract Background Acute pancreatitis (AP) is the largest contributor to diabetes of the exocrine pancreas. However, there is no accurate predictor at the time of hospitalisation for AP to identify individuals at high risk for… read more here.
Keywords: study; variability; onset diabetes; early course ... See more keywords
Diabetic Hepatosclerosis in a Woman with Maturity-Onset Diabetes of the Young Type 3
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-07005-2
Abstract: Diabetic hepatosclerosis (DHS), initially described in 2006, represents a form of diabetic microangiopathy of the liver found in patients with long-standing diabetes mellitus with other microvascular complications [1]. DHS is characterized by hepatic sinusoidal fibrosis… read more here.
Keywords: diabetes young; young type; onset diabetes; maturity onset ... See more keywords
Maturity Onset Diabetes of the Young is Not Necessarily Associated with Autosomal Inheritance: Case Description of a De Novo HFN1A Mutation
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes Therapy"
DOI: 10.1007/s13300-019-0633-3
Abstract: Maturity onset diabetes of the young (MODY) accounts for up to 4% of all cases of diabetes in pediatric patients. MODY is usually characterized by autosomal dominant inheritance, impaired insulin secretion, and an average age… read more here.
Keywords: diabetes young; onset diabetes; maturity onset; case ... See more keywords
Missense Variants in PAX4 Are Associated with Early-Onset Diabetes in Chinese
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00960-5
Abstract: Introduction East Asians are more susceptible to early-onset diabetes than Europeans and exhibit reduced insulin secretion at earlier stages. PAX4 plays a critical role in the development of β-cells. The dysfunction-missense variants PAX4 R192H and… read more here.
Keywords: east asians; onset diabetes; early onset; pax4 r192h ... See more keywords
New-Onset Diabetes in COVID-19: Time to Frame Its Fearful Symmetry
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes Therapy"
DOI: 10.1007/s13300-020-00988-7
Abstract: There is increasing evidence that coronavirus disease 2019 (COVID-19) may lead to new-onset diabetes mellitus (DM). This may occur even in patients without predisposing factors for impaired glucose metabolism. Both impaired pancreatic insulin secretion and… read more here.
Keywords: onset diabetes; covid time; time frame; frame fearful ... See more keywords
Ocular surface assessment in maturity-onset diabetes of the young
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-020-00843-2
Abstract: Aim To examine ocular surface changes in patients with maturity-onset diabetes of young (MODY). Material and methods Fifty patients with MODY who were transferred to Genetic Diagnosis Department of Diskapi Yildirim Beyazit Training and Research… read more here.
Keywords: ocular surface; diabetes young; onset diabetes; maturity onset ... See more keywords
GLP-2 restores impairments in spatial working memory and hippocampal LTD via the MEK/ERK pathway in juvenile-onset diabetes rats
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113235
Abstract: Type 1 diabetic animal models, generated by injecting streptozotocin (STZ), have been widely used in research. We previously reported that juvenile-onset diabetes mellitus (JDM) rats, which were prepared by administering STZ to 17-day-old rats, developed… read more here.
Keywords: impairments spatial; glp; onset diabetes; working memory ... See more keywords
COVID-19-INDUCED NEW ONSET DIABETES MELLITUS
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.07.589
Abstract: TOPIC: Critical Care TYPE: Fellow Case Reports INTRODUCTION: COVID-19 infection and diabetes have been intertwined closely since the onset of the pandemic. Presence of diabetes as comorbidity has made infected individuals more prone to severe… read more here.
Keywords: onset diabetes; infection; damage; new onset ... See more keywords
Novel strategies for glycaemic control and preventing diabetic complications applying the clustering-based classification of adult-onset diabetes mellitus: A perspective.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2021.109067
Abstract: Diabetes mellitus results from an interplay between insulin resistance and β-cell dysfunction. Since their relative contributions to its pathogenesis are difficult to quantify, therapeutic strategies for glycaemic control are determined primarily based on two limited… read more here.
Keywords: adult onset; strategies glycaemic; onset diabetes; glycaemic control ... See more keywords