Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.005
Abstract: Male late-onset hypogonadism (LOH) is reported as one of the most common age-related diseases occurred in middle-aging men. Testosterone replacement therapy (TRT) is currently the main clinical treatment for LOH, however it has obvious side… read more here.
Keywords: late onset; fused tricyclic; methylpyrimidine fused; tricyclic diterpene ... See more keywords
The CATCH checklist to investigate adult‐onset hypogonadism
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DOI: 10.1111/andr.12506
Abstract: Adult‐onset hypogonadism is a syndrome often underdiagnosed, undertreated, or incompletely explored. There are various reasons for this: firstly, undefined age range of men in whom testosterone levels should be investigated and then no definitive serum… read more here.
Keywords: catch checklist; adult onset; onset hypogonadism; hypogonadism ... See more keywords
Late‐onset hypogonadism: Prostate safety
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DOI: 10.1111/andr.12772
Abstract: There have always been concerns regarding testosterone replacement therapy and prostate safety because of the central role of testosterone in prostate tissue. Even though there is a body of evidence supporting that the benefits of… read more here.
Keywords: late onset; hypogonadism prostate; safety; testosterone ... See more keywords
Late‐onset Hypogonadism: Bone health
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DOI: 10.1111/andr.12827
Abstract: Bone health is underdiagnosed and undermanaged in men. Bone loss occurs in men with hypogonadism and in aging men. Thus, patients with a diagnosis of late‐onset hypogonadism (LOH) are at risk of osteoporosis and osteoporotic… read more here.
Keywords: bone health; late onset; onset hypogonadism; hypogonadism ... See more keywords
Multi-Institutional Survey of Medical Treatment for Late-Onset Hypogonadism in Japan
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Men's Health"
DOI: 10.1177/1557988316681668
Abstract: The adequate criteria for late-onset hypogonadism (LOH) diagnosis, including serum testosterone levels, type (total or free testosterone) and duration of androgen replacement therapy, and evaluations of treatment effectiveness remain controversial. To evaluate the current status… read more here.
Keywords: late onset; medical treatment; treatment; japan ... See more keywords
Investigating the basis of sexual dysfunction during late-onset hypogonadism
Sign Up to like & getrecommendations! Published in 2019 at "F1000Research"
DOI: 10.12688/f1000research.16561.1
Abstract: Late-onset hypogonadism (LOH) is the term used to describe the decline in serum testosterone levels associated with increasing age in men above 40 years. A number of symptoms are attributed to LOH, but the most… read more here.
Keywords: late onset; sexual dysfunction; investigating basis; dysfunction ... See more keywords
Novel testosterone gel improves serum testosterone concentrations and aging males' symptoms in patients with late-onset hypogonadism: an active control equivalence, randomized, double-blind, crossover study.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine journal"
DOI: 10.1507/endocrj.ej22-0497
Abstract: Late-onset hypogonadism (LOH) is generally treated with testosterone replacement therapy. Intramuscular injection of testosterone enanthate is used for LOH in Japan but requires regular painful injections administered every 2-3 weeks at a clinic. Testosterone 2%… read more here.
Keywords: onset hypogonadism; serum testosterone; testosterone concentrations; testosterone ... See more keywords
Late-Onset Hypogonadism as Primary Testicular Failure
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00372
Abstract: Testosterone (T) therapy has garnered widespread public enthusiasm and media attention due to its potential role in age-related T decline in men, commonly known as late-onset hypogonadism (LOH), andropause, or low T syndrome. The serum… read more here.
Keywords: late onset; primary testicular; hypogonadism primary; onset hypogonadism ... See more keywords
The relationship between exposure to phthalate metabolites and adult-onset hypogonadism
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DOI: 10.3389/fendo.2022.991497
Abstract: Objective Adult-onset hypogonadism (AOH) is a common disease for males >40 years old and is closely associated with age-related comorbidities. Phthalates are compounds widely used in a number of products with endocrine-disrupting effects. However, little… read more here.
Keywords: onset hypogonadism; phthalate; adult onset; phthalate metabolites ... See more keywords
Predictive factors for efficacy of testosterone replacement therapy for late-onset hypogonadism in Japanese men: a preliminary report.
Sign Up to like & getrecommendations! Published in 2023 at "Asian journal of andrology"
DOI: 10.4103/aja2022123
Abstract: Although testosterone replacement therapy (TRT) is the first-choice method used worldwide for late-onset hypogonadism (LOH), clinical benefits are not seen in all cases. This study was conducted to determine the predictors of TRT efficacy for… read more here.
Keywords: onset hypogonadism; trt; replacement therapy; ratio ... See more keywords