Effect of Dimethyl Fumarate vs Interferon β-1a in Patients With Pediatric-Onset Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.30439
Abstract: This randomized clinical trial investigates the efficacy and safety of dimethyl fumarate vs interferon β-1a for treatment of pediatric-onset multiple sclerosis. read more here.
Keywords: onset multiple; pediatric onset; multiple sclerosis; dimethyl fumarate ... See more keywords
miRNA contributions to pediatric‐onset multiple sclerosis inferred from GWAS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.786
Abstract: Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped‐MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding… read more here.
Keywords: contributions pediatric; mirna contributions; multiple sclerosis; onset multiple ... See more keywords
Newer Treatment Approaches in Pediatric-Onset Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Current Treatment Options in Neurology"
DOI: 10.1007/s11940-019-0592-z
Abstract: With the recognition that pediatric-onset multiple sclerosis (POMS) is characterized by more prominent disease activity, earlier age at onset of disability milestones, and more prominent cognitive impairment compared with physical disability earlier in the disease… read more here.
Keywords: treatment; multiple sclerosis; treatment approaches; onset multiple ... See more keywords
Recent Onset of Multiple Asymptomatic Brownish Papules.
Sign Up to like & getrecommendations! Published in 2019 at "Actas dermo-sifiliograficas"
DOI: 10.1016/j.ad.2018.06.029
Abstract: Dermoscopy revealed a homogeneous clear brown area with a delicate pigment network (Fig. 2A). High-frequency ultrasound (18 MHz, MyLab 25Gold, Esaote) revealed well-defined oval lesions in the superficial dermis. These were slightly hypoechogenic with respect… read more here.
Keywords: brownish papules; multiple asymptomatic; recent onset; asymptomatic brownish ... See more keywords
Paediatric onset of multiple sclerosis: Analysis of chemokine and cytokine levels in the context of the early clinical course.
Sign Up to like & getrecommendations! Published in 2020 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2020.102467
Abstract: BACKGROUND Inflammatory activity in children with paediatric onset multiple sclerosis (POMS) is higher than that in adults with MS. Chemokine/cytokine profiling in children may provide new insights into the disease pathogenesis and clinical course. The… read more here.
Keywords: sclerosis; paediatric onset; time; course ... See more keywords
COVID-19 in a temporal relation to the onset of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Multiple Sclerosis and Related Disorders"
DOI: 10.1016/j.msard.2021.102863
Abstract: Neurological complications of COVID-19 have been described. We present the case of a 27-year-old woman who developed COVID-19 in April 2020. She continued to present anosmia and ageusia eight months later. Six months after contracting… read more here.
Keywords: sclerosis; temporal relation; relation onset; multiple sclerosis ... See more keywords
Update on pediatric-onset multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "Revue neurologique"
DOI: 10.1016/j.neurol.2018.04.003
Abstract: Pediatric-onset multiple sclerosis (POMS) has distinctive features compared with adult-onset multiple sclerosis (AOMS), and warrants caution despite being a rare form of MS. POMS diagnostic criteria are somewhat different from those used in AOMS, with… read more here.
Keywords: multiple sclerosis; onset multiple; pediatric onset; update pediatric ... See more keywords
Evaluation of white matter microstructure in pediatric onset multiple sclerosis with diffusion compartment imaging
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimaging"
DOI: 10.1111/jon.13038
Abstract: Pediatric‐onset multiple sclerosis (POMS) shows earlier axonal involvement and greater axonal loss than in adults. We aim to characterize the white matter (WM) microstructural changes in POMS using a diffusion compartment imaging (DCI) model and… read more here.
Keywords: diffusion; onset multiple; pediatric onset; white matter ... See more keywords
PedsQL Multiple Sclerosis Module Domain and Item Development: Qualitative Methods
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Child Neurology"
DOI: 10.1177/08830738211015016
Abstract: Background: The objective of this qualitative methods study was to develop the domains and items to support the content validity for the Pediatric Quality of Life Inventory (PedsQL) Multiple Sclerosis Module for youth with pediatric-onset… read more here.
Keywords: sclerosis; module; multiple sclerosis; onset multiple ... See more keywords
Six-Minute Walk Performance and Related Factors in Pediatric-Onset Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of child neurology"
DOI: 10.1177/08830738211072701
Abstract: OBJECTIVE To investigate functional exercise capacity and its relationship between physical activity levels, muscle strength, balance, fatigue, and quality of life in patients with pediatric-onset multiple sclerosis. METHODS Fifteen patients with pediatric-onset multiple sclerosis were… read more here.
Keywords: minute walk; pediatric onset; fatigue; onset multiple ... See more keywords
Long-term disability progression of pediatric-onset multiple sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007647
Abstract: Objective To evaluate long-term disability progression in pediatric-onset multiple sclerosis (POMS) and compare to adult-onset multiple sclerosis (AOMS). Methods This was a retrospective cohort study using prospectively collected clinical information from the Swedish MS Registry.… read more here.
Keywords: progression; disability; onset multiple; pediatric onset ... See more keywords