Age Cutoff for Early‐Onset Parkinson's Disease: Recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13523
Abstract: Early‐onset Parkinson's disease (EOPD)/young‐onset Parkinson's disease (YOPD) is defined as Parkinson's disease (PD) with an age at onset (AAO) after age 21 years but before the usual AAO for PD. Consensus is lacking, and the reported… read more here.
Keywords: disease; onset parkinson; early onset; parkinson disease ... See more keywords
Rare and novel variants of PRKN and PINK1 genes in Vietnamese patients with early‐onset Parkinson’s disease
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DOI: 10.1002/mgg3.1463
Abstract: Early‐onset Parkinson's disease (EOPD) refers to that of patients who have been diagnosed or had onset of motor symptoms before age 50, accounting for 4% of Parkinson's disease patients. The PRKN and PINK1 genes, both… read more here.
Keywords: pink1 genes; onset parkinson; early onset; disease ... See more keywords
Real-world pharmacological treatment patterns of patients with young-onset Parkinson’s disease in Japan: a medical claims database analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurology"
DOI: 10.1007/s00415-019-09360-7
Abstract: IntroductionYoung-onset Parkinson’s disease is reported to comprise 5–10% of all Parkinson’s disease cases; however, as physicians encounter a limited number of these patients, their treatment patterns are still unclear.MethodsWe performed a descriptive study using the… read more here.
Keywords: onset parkinson; disease; young onset; parkinson disease ... See more keywords
ATP13A2 novel mutations causing a rare form of juvenile-onset Parkinson disease
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DOI: 10.1016/j.braindev.2018.05.017
Abstract: Parkinson disease is a common neurodegenerative disease that typically starts around the age of 60 years; however, juvenile-onset disease can occur rarely. Although Parkinson disease is typically sporadic; in rare occasions, it can be caused by… read more here.
Keywords: onset parkinson; novel mutations; disease; parkinson disease ... See more keywords
PINK1 p.K520RfsX3 mutation identified in a Chinese family with early-onset Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.04.020
Abstract: Parkinson's disease (PD) features selective loss of dopaminergic neurons of the substantia nigra pars compacta accompanied by the accumulation and aggregation of alpha-synuclein in Lewy bodies. PTEN induced putative kinase 1 gene (PINK1) mutations are… read more here.
Keywords: onset parkinson; early onset; family; parkinson disease ... See more keywords
Impact of subthalamic nucleus stimulation did not differ on young-onset and older-onset Parkinson's disease: A three-year follow up
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.04.041
Abstract: OBJECTIVE To assess the role of onset age in the results of bilateral subthalamic nucleus deep brain stimulation (STN-DBS), we carried out a retrospective study of two groups of patients regarding age at disease onset.… read more here.
Keywords: onset parkinson; stimulation; disease; parkinson disease ... See more keywords
Genetic analysis of PODXL gene in patients with familial and young-onset Parkinson's disease in a Taiwanese population
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.08.027
Abstract: Mutations in the podocalyxin-like gene (PODXL) have been recently identified in a consanguineous Indian family with juvenile-onset Parkinson's disease (PD) and 3 unrelated patients with PD. However, the pathogenicity of PODXL mutations in the disease… read more here.
Keywords: onset parkinson; young onset; taiwanese population; parkinson disease ... See more keywords
Saccadic Eye Movements in Young-Onset Parkinson’s Disease - A BOLD fMRI Study
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Ophthalmology"
DOI: 10.1080/01658107.2019.1652656
Abstract: ABSTRACT The objective of the present study was to understand control of saccadic eye movements in patients with young onset Parkinson’s disease (YOPD) where onset of disease symptoms appears early in life ( read more here.
Keywords: onset parkinson; eye movements; disease; young onset ... See more keywords
Young Onset Parkinson’s Disease: A Modern and Tailored Approach
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DOI: 10.3233/jpd-202135
Abstract: In people with young onset Parkinson’s disease (YOPD), onset of symptoms is between 21 and 40 years of age. The distinction between YOPD and late-onset Parkinson’s disease is supported by genetic differences (a genetic etiology… read more here.
Keywords: young onset; disease modern; parkinson disease; onset parkinson ... See more keywords
Early-Onset Parkinson's Disease and Brain Iron Accumulation Caused by a Novel Homozygous DJ-1 Mutation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-213033
Abstract: DJ-1 mutations are rare causes of autosomal recessive early-onset Parkinson's disease (AR-EOPD) and relatively rarely reported in the Chinese population. Here, we used the whole-exome sequencing and Sanger sequencing to investigate DJ-1 mutations in the… read more here.
Keywords: onset parkinson; early onset; parkinson disease; brain ... See more keywords
People with Early Onset Parkinson's Disease: Empowered to Improve Care.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-230039
Abstract: Patient organizations play an ever-growing role in modern societies by providing organized resources for patients and care partners. Importantly, patient organizations enable patients to define and share their needs and views. In Parkinson's disease (PD),… read more here.
Keywords: disease; onset parkinson; early onset; parkinson disease ... See more keywords