Efficacy and safety of perampanel monotherapy in patients with focal‐onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: The open‐label Study 342 (FREEDOM Study)
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DOI: 10.1002/epi4.12398
Abstract: Our study assessed perampanel monotherapy in patients (aged ≥12 years) with focal‐onset seizures (FOS) with or without focal to bilateral tonic‐clonic seizures (FBTCS) in Japan and South Korea. read more here.
Keywords: epilepsy; monotherapy patients; perampanel monotherapy; study ... See more keywords
Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention
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DOI: 10.1002/epi4.12987
Abstract: A growing body of evidence suggests patients with late‐onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. We aim to… read more here.
Keywords: onset seizures; risk; risk factor; late onset ... See more keywords
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)
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DOI: 10.1002/epi4.70068
Abstract: The AMPA study (Study 501; NCT04257604) was a multicenter, prospective, 12‐month observational study in Italy that evaluated the effectiveness and safety of adjunctive perampanel in patients with focal‐onset seizures (FOS), with or without focal to… read more here.
Keywords: focal onset; perampanel; onset seizures; study ... See more keywords
Autoimmune and paraneoplastic encephalitis-associated neuronal autoantibodies with serial EEG in adults with unexplained new-onset seizures or worsening epilepsy.
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DOI: 10.1002/epi4.70173
Abstract: Unexplained seizures or worsening epilepsy in adult patients may be associated with specific neuronal or onconeuronal antibodies. We propose that comprehensive antibody testing is beneficial for adults with new‐onset seizures or aggravated epilepsy without a… read more here.
Keywords: new onset; onset seizures; seizures worsening; worsening epilepsy ... See more keywords
When Opportunity Strikes: A Case of a 67-year-old with History of Cardiac Transplant Developing New-onset Seizures
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DOI: 10.1016/j.cardfail.2020.09.316
Abstract: Introduction Many known risks are associated with cardiac transplantation. Although dangers surround the transplant itself, immunosuppression increases the vulnerability to infection and malignancy. Without expertise in transplant medicine, diagnosing and managing patients with complications of… read more here.
Keywords: medicine; year old; transplant; onset seizures ... See more keywords
PND43 THE BURDEN OF PEDIATRIC PARTIAL ONSET SEIZURES: A REVIEW OF THE LITERATURE
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DOI: 10.1016/j.jval.2019.04.1316
Abstract: CONCLUSIONS • To better understand the burden of epilepsy among 2to 12year-olds, we conducted a targeted literature review summarizing humanistic and economic outcomes. Data specific to POS are presented here. • Using MeSH and text… read more here.
Keywords: pediatric partial; onset seizures; partial onset; pnd43 burden ... See more keywords
Quality of life study for caregivers of people with uncontrolled focal-onset seizures.
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DOI: 10.1080/13696998.2021.2018871
Abstract: AIM The aim of this study was to capture and measure the impact of caregiving for an adult with uncontrolled drug-resistant focal-onset seizures (FOS) on the caregivers' quality of life (QoL), and to quantify the… read more here.
Keywords: study; quality life; focal onset; onset seizures ... See more keywords
Improved Patient-Independent System for Detection of Electrical Onset of Seizures
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DOI: 10.1097/wnp.0000000000000533
Abstract: Purpose: To design a non–patient-specific system to detect the electrical onset of seizures in patients with temporal lobe epilepsy. Methods: We used EEG data from 29 seizures of 18 temporal lobe epilepsy patients who underwent… read more here.
Keywords: system; electrical onset; onset seizures; epilepsy ... See more keywords
Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures
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DOI: 10.1111/ane.12874
Abstract: Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial‐onset seizures (POS) and identify factors explaining between‐subject variability in efficacy using a population PK/pharmacodynamic (PD) analysis. read more here.
Keywords: partial onset; perampanel; pharmacodynamic analysis; onset seizures ... See more keywords
Adjunctive perampanel in partial‐onset seizures: Asia‐Pacific, randomized phase III study
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DOI: 10.1111/ane.12883
Abstract: To evaluate the efficacy, safety, and tolerability of perampanel, a selective, non‐competitive, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonist, as an adjunctive treatment for patients with refractory partial‐onset seizures (POS) from Asia‐Pacific. read more here.
Keywords: asia pacific; adjunctive perampanel; partial onset; onset seizures ... See more keywords
Hemispheric differences in the duration of focal onset seizures
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DOI: 10.1111/ane.13356
Abstract: To assess hemispheric differences in the duration of focal onset seizures and its association with clinical and demographic factors. read more here.
Keywords: differences duration; focal onset; hemispheric differences; onset seizures ... See more keywords