Efficacy and safety of perampanel monotherapy in patients with focal‐onset seizures with newly diagnosed epilepsy or recurrence of epilepsy after a period of remission: The open‐label Study 342 (FREEDOM Study)
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DOI: 10.1002/epi4.12398
Abstract: Our study assessed perampanel monotherapy in patients (aged ≥12 years) with focal‐onset seizures (FOS) with or without focal to bilateral tonic‐clonic seizures (FBTCS) in Japan and South Korea. read more here.
Keywords: epilepsy; monotherapy patients; perampanel monotherapy; study ... See more keywords
When Opportunity Strikes: A Case of a 67-year-old with History of Cardiac Transplant Developing New-onset Seizures
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DOI: 10.1016/j.cardfail.2020.09.316
Abstract: Introduction Many known risks are associated with cardiac transplantation. Although dangers surround the transplant itself, immunosuppression increases the vulnerability to infection and malignancy. Without expertise in transplant medicine, diagnosing and managing patients with complications of… read more here.
Keywords: medicine; year old; transplant; onset seizures ... See more keywords
PND43 THE BURDEN OF PEDIATRIC PARTIAL ONSET SEIZURES: A REVIEW OF THE LITERATURE
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DOI: 10.1016/j.jval.2019.04.1316
Abstract: CONCLUSIONS • To better understand the burden of epilepsy among 2to 12year-olds, we conducted a targeted literature review summarizing humanistic and economic outcomes. Data specific to POS are presented here. • Using MeSH and text… read more here.
Keywords: pediatric partial; onset seizures; partial onset; pnd43 burden ... See more keywords
Quality of life study for caregivers of people with uncontrolled focal-onset seizures.
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DOI: 10.1080/13696998.2021.2018871
Abstract: AIM The aim of this study was to capture and measure the impact of caregiving for an adult with uncontrolled drug-resistant focal-onset seizures (FOS) on the caregivers' quality of life (QoL), and to quantify the… read more here.
Keywords: study; quality life; focal onset; onset seizures ... See more keywords
Improved Patient-Independent System for Detection of Electrical Onset of Seizures
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DOI: 10.1097/wnp.0000000000000533
Abstract: Purpose: To design a non–patient-specific system to detect the electrical onset of seizures in patients with temporal lobe epilepsy. Methods: We used EEG data from 29 seizures of 18 temporal lobe epilepsy patients who underwent… read more here.
Keywords: system; electrical onset; onset seizures; epilepsy ... See more keywords
Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures
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DOI: 10.1111/ane.12874
Abstract: Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial‐onset seizures (POS) and identify factors explaining between‐subject variability in efficacy using a population PK/pharmacodynamic (PD) analysis. read more here.
Keywords: partial onset; perampanel; pharmacodynamic analysis; onset seizures ... See more keywords
Adjunctive perampanel in partial‐onset seizures: Asia‐Pacific, randomized phase III study
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DOI: 10.1111/ane.12883
Abstract: To evaluate the efficacy, safety, and tolerability of perampanel, a selective, non‐competitive, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonist, as an adjunctive treatment for patients with refractory partial‐onset seizures (POS) from Asia‐Pacific. read more here.
Keywords: asia pacific; adjunctive perampanel; partial onset; onset seizures ... See more keywords
Hemispheric differences in the duration of focal onset seizures
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DOI: 10.1111/ane.13356
Abstract: To assess hemispheric differences in the duration of focal onset seizures and its association with clinical and demographic factors. read more here.
Keywords: differences duration; focal onset; hemispheric differences; onset seizures ... See more keywords
VAERS‐reported new‐onset seizures following use of COVID‐19 vaccinations as compared to influenza vaccinations
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DOI: 10.1111/bcp.15415
Abstract: The incidence of new‐onset seizures, which we defined as de novo seizures occurring within 4 weeks of receiving any of the US Food and Drug Administration‐approved COVID‐19 vaccinations as reported in patient‐reported data compiled in the… read more here.
Keywords: onset seizures; covid vaccinations; new onset; vaers reported ... See more keywords
Brivaracetam: a novel antiepileptic drug for focal-onset seizures
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DOI: 10.1177/1756285617742081
Abstract: Brivaracetam (BRV), the n-propyl analogue of levetiracetam (LEV), is the latest antiepileptic drug (AED) to be licensed in Europe and the USA for the adjunctive treatment of focal-onset seizures with or without secondary generalization in… read more here.
Keywords: drug; focal onset; onset seizures; brv ... See more keywords
Developing a Conceptual Disease Model of Patient Experiences and Identifying Patient-Reported Clinical Outcome Assessments for Use in Trials of Treatments for Focal Onset Seizures
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DOI: 10.2147/ndt.s354031
Abstract: Purpose To identify concepts important to understanding the experiences of adults with focal onset seizures (FOS) and evaluate clinical outcome assessments (COAs) for measuring these concepts in clinical trials of treatments for FOS. Methods A… read more here.
Keywords: focal onset; onset seizures; clinical trials; disease ... See more keywords