Effects of mitochondria‐associated Ca2+ transporters suppression on oocyte activation
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3571
Abstract: Oocyte activation deficiency leads to female infertility. [Ca2+]i oscillations are required for mitochondrial energy supplement transition from the resting to the excited state, but the underlying mechanisms are still very little known. Three mitochondrial Ca2+… read more here.
Keywords: associated ca2; effects mitochondria; mitochondria associated; ca2 ... See more keywords
Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen–thawed embryo transfer: a 6-year population-based retrospective study
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-019-05298-3
Abstract: To evaluate the impact of artificial oocyte activation (AOA) in pregnancy and neonatal outcomes in infertile patients undergoing cryopreserved embryo transfer. This retrospective study included 5686 patients’ transferred embryos from routine intracytoplasmic sperm injection (ICSI)… read more here.
Keywords: pregnancy; artificial oocyte; icsi; neonatal outcomes ... See more keywords
Calcium Oscillatory Patterns and Oocyte Activation During Fertilization: a Possible Mechanism for Total Fertilization Failure (TFF) in Human In Vitro Fertilization?
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00293-5
Abstract: This paper reviews the effects of calcium oscillatory patterns in oocytes and early embryo development. Total fertilization failure (TFF) is the failure of fertilization in all oocytes in a human IVF cycle, even after treatment… read more here.
Keywords: fertilization; calcium oscillatory; oscillatory patterns; calcium ... See more keywords
Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection: a 17-year retrospective study.
Sign Up to like & getrecommendations! Published in 2019 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2019.04.006
Abstract: OBJECTIVE To investigate the extent to which assisted oocyte activation (AOA) improves clinical outcomes in patients diagnosed with oocyte activation deficiencies (OADs). DESIGN Retrospective cohort study comparing AOA cycles and previous intracytoplasmic sperm injection (ICSI)… read more here.
Keywords: fertilization; low total; pregnancy; moat ... See more keywords
Phospholipase C zeta 1 mRNA as a marker of oocyte-activation and fertilization potential of water buffalo (Bubalus bubalis) semen
Sign Up to like & getrecommendations! Published in 2019 at "Livestock Science"
DOI: 10.1016/j.livsci.2019.04.011
Abstract: Abstract The present study aimed to detect and quantify the expression of buffalo PLCZ1 mRNA (buPLCZ1 mRNA) in buffalo semen and to determine its oocyte-activation and fertilizing ability through IVF. Buffalo semen samples were collected… read more here.
Keywords: expression; buffalo; oocyte activation; mrna ... See more keywords
Mitochondrial regulation of [Ca2+]i oscillations during cell cycle resumption of the second meiosis of oocyte
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1489179
Abstract: ABSTRACT Oocyte is arrested at metaphase of the second meiosis until fertilization switching on [Ca2+]i oscillations. Oocyte activation inefficiency is the most challenging problem for failed fertilization and embryonic development. Mitochondrial function and intracellular [Ca2+]i… read more here.
Keywords: mitochondrial function; second meiosis; ca2; ca2 oscillations ... See more keywords
The effect of ionomycin-induced oocyte activation on multiple morphological abnormalities of the sperm flagella
Sign Up to like & getrecommendations! Published in 2023 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2023.2167621
Abstract: Abstract Artificial oocyte activation (AOA) is considered an effective method to improve clinical outcomes in patients with some forms of male factor infertility and does not increase the risk of birth defects. However, the effects… read more here.
Keywords: clinical outcomes; oocyte activation; multiple morphological; abnormalities sperm ... See more keywords
Significant differences in efficiency between two commonly used ionophore solutions for assisted oocyte activation (AOA): a prospective comparison of ionomycin and A23187.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of assisted reproduction and genetics"
DOI: 10.1093/humrep/deac107.204
Abstract: PURPOSE Despite the success of ICSI in treating severe male factor infertile patients, total fertilization failure (FF) still occurs in around 1-3% of ICSI cycles. To overcome FF, the use of calcium ionophores has been… read more here.
Keywords: a23187; oocyte activation; assisted oocyte; ionomycin ... See more keywords
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation.
Sign Up to like & getrecommendations! Published in 2023 at "Human reproduction update"
DOI: 10.1093/humupd/dmad007
Abstract: BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1-3% of ICSI cycles. Oocyte activation deficiency (OAD)… read more here.
Keywords: oocyte activation; fertilization failure; failure; aoa ... See more keywords
Ionomycin induced mouse oocyte activation can disrupt preimplantation embryo development through increased reactive oxygen species reaction and DNA damage.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaaa056
Abstract: Oocyte activation induced by calcium oscillations is an important process in normal fertilization and subsequent embryogenesis. In the clinical assisted reproduction, artificial oocyte activation (AOA) is an effective method to improve the clinical outcome of… read more here.
Keywords: preimplantation embryo; embryo development; development; oocyte activation ... See more keywords
Phospholipase C zeta (PLCζ) and the clinical diagnosis of oocyte activation deficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Reproduction"
DOI: 10.1530/rep-21-0458
Abstract: Oocyte activation deficiency (OAD) remains the predominant cause of total/low fertilization rate in assisted reproductive technology (ART). Phospholipase C zeta (PLCζ) is the dominant sperm-specific factor responsible for triggering oocyte activation in mammals. OAD has… read more here.
Keywords: activation; plc; oocyte activation; activation deficiency ... See more keywords