The impact of oocyte death on mouse primordial follicle formation and ovarian reserve
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12489
Abstract: Ovaries, the source of oocytes, maintain the numbers of primordial follicles, develop oocytes for fertilization and embryonic development. Although it is well known that about two‐thirds of oocytes are lost during the formation of primordial… read more here.
Keywords: impact oocyte; mouse primordial; oocyte death; formation ... See more keywords
TAp63 determines the fate of oocytes against DNA damage
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.ade1846
Abstract: Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target effect. However, their oocyte death pathway has been debated. Here, we clarified the precise mechanism of ovarian depletion induced by cyclophosphamide and doxorubicin. Dormant… read more here.
Keywords: cyclophosphamide doxorubicin; dna damage; tap63 determines; oocyte death ... See more keywords
A pannexin 1 channelopathy causes human oocyte death
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DOI: 10.1126/scitranslmed.aav8731
Abstract: Inherited dominant mutations in PANX1 cause female infertility characterized by oocyte death. A vital gene for oocytes Infertility is common in both males and females, but the biological causes of female infertility are not as… read more here.
Keywords: death; pannexin; female infertility; human oocyte ... See more keywords
A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-024-01462-9
Abstract: Pannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions. Variants in the PANX1 gene have been reported to be associated with oocyte death… read more here.
Keywords: human oocyte; variant; panx1; novel heterozygous ... See more keywords