Guardians of the oocyte methylome
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0090-2
Abstract: STELLA protects the genome of mouse oocytes from de novo DNA methylation by the E3 ubiquitin ligase UHRF1 and the DNA methyltransferase DNMT1. read more here.
Keywords: biology; guardians oocyte; oocyte methylome;
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0751-5
Abstract: Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA methylation, which is predominantly mediated by DNMT3A, a de novo DNA methyltransferase1,2. Unlike the genome of sperm and most somatic cells, the… read more here.
Keywords: methylation; oocyte methylome; dna; stella ... See more keywords