Abstract 276: Maternal High Fat, High Sucrose Diet-induced Cardiac Mitochondrial Abnormalities in the Offspring are Transmitted via the Oocyte Nucleus
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.276
Abstract: Introduction: Maternal obesity correlates with higher cardiovascular disease risk in human offspring. We found high fat, high sucrose (HF/HS) diet results in accretion of abnormal mitochondria in mouse oocytes, and chow-fed offspring of HF/HS-fed dams… read more here.
Keywords: fed dams; oocyte nucleus; cardiac mitochondrial; high fat ... See more keywords
The prophase oocyte nucleus is a homeostatic G-actin buffer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259807
Abstract: Formation of healthy mammalian eggs from oocytes requires specialised F-actin structures. F-actin disruption produces aneuploid eggs, which are a leading cause of human embryo deaths, genetic disorders, and infertility. We found that oocytes contain prominent… read more here.
Keywords: actin; nuclear actin; nucleus homeostatic; oocyte nucleus ... See more keywords