Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect
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DOI: 10.1007/s43032-020-00360-x
Abstract: Nlrp2 encodes a protein of the oocyte subcortical maternal complex (SCMC), required for embryo development. We previously showed that loss of maternal Nlrp2 in mice causes subfertility, smaller litters with birth defects, and growth abnormalities… read more here.
Keywords: nlrp2 deficient; deficient females; deficient; reproductive outcomes ... See more keywords
Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation
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DOI: 10.1016/j.stemcr.2017.09.012
Abstract: Summary Mammalian oocytes possess fascinating unknown factors, which can reprogram terminally differentiated germ cells or somatic cells into totipotent embryos. Here, we demonstrate that oocyte-specific homeobox 1 (Obox1), an oocyte-specific factor, can markedly enhance the… read more here.
Keywords: hyperproliferation; oocyte specific; specific homeobox; cell ... See more keywords
Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation
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DOI: 10.3389/fendo.2022.1047498
Abstract: Background Adrenomedullin 2 (ADM2), adrenomedullin (ADM), and calcitonin gene-related peptides (α- and β-CGRPs) signal through heterodimeric calcitonin receptor-like receptor/receptor activity-modifying protein 1, 2 and 3 (CLR/RAMP1, 2 and 3) complexes. These peptides are important regulators… read more here.
Keywords: superovulation; disruption; adm2; oocyte specific ... See more keywords
Oocyte-Specific Knockout of Histone Lysine Demethylase KDM2a Compromises Fertility by Blocking the Development of Follicles and Oocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231912008
Abstract: The methylation status of histones plays a crucial role in many cellular processes, including follicular and oocyte development. Lysine-specific demethylase 2a (KDM2a) has been reported to be closely associated with gametogenesis and reproductive performance, but… read more here.
Keywords: development; kdm2a cko; demethylase kdm2a; follicles oocytes ... See more keywords