Metformin promotes in vitro maturation of oocytes from aged mice by attenuating mitochondrial oxidative stress via SIRT3-dependent SOD2ac
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1028510
Abstract: Human female fecundity decreases irreversibly as chronological age rises, adversely affecting oocyte quality, consequently worsening pregnancy outcomes and increasing the extent of birth defects. The first-line type 2 diabetes treatment metformin has been associated with… read more here.
Keywords: oocytes aged; oxidative stress; aged mice; metformin ... See more keywords
Increased Expression of Maturation Promoting Factor Components Speeds Up Meiosis in Oocytes from Aged Females
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DOI: 10.3390/ijms19092841
Abstract: The rate of chromosome segregation errors that emerge during meiosis I in the mammalian female germ line are known to increase with maternal age; however, little is known about the underlying molecular mechanism. The objective… read more here.
Keywords: aged females; oocytes aged; expression maturation; meiosis ... See more keywords