Sirt3 modulate renal ischemia‐reperfusion injury through enhancing mitochondrial fusion and activating the ERK‐OPA1 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28918
Abstract: Mitochondrial fusion is linked to heart and liver ischemia‐reperfusion (IR) insult. Unfortunately, there is no report to elucidate the detailed influence of mitochondrial fusion in renal IR injury. This study principally investigated the mechanism by… read more here.
Keywords: opa1; mitochondrial fusion; renal injury; fusion ... See more keywords
Analysis of Mitochondrial Membrane Fusion GTPase OPA1 Expressed by the Silkworm Expression System.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0676-6_9
Abstract: Mitochondria are highly dynamic organelles, which move and fuse to regulate their shape, size, and fundamental function. The dynamin-related GTPases play a critical role in mitochondrial membrane fusion. In vitro reconstitution of membrane fusion using… read more here.
Keywords: opa1; membrane fusion; expression; fusion ... See more keywords
Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102055
Abstract: Background Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria. OPA1 is the… read more here.
Keywords: opa1 isoforms; opa1; copd; inner mitochondrial ... See more keywords
Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00709
Abstract: Mitochondria are highly dynamic organelles with coordinated cycles of fission and fusion occurring continuously to satisfy the energy demands in the complex architecture of neurons. How mitochondria contribute to addicted drug-induced adaptable mitochondrial networks and… read more here.
Keywords: induced locomotor; fusion; opa1; neuronal mitochondrial ... See more keywords
OPA1 Regulates Lipid Metabolism and Cold-Induced Browning of White Adipose Tissue in Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0450
Abstract: Mitochondria play a vital role in white adipose tissue homeostasis including adipogenesis, fatty acid synthesis, and lipolysis. We recently reported that the mitochondrial fusion protein optic atrophy 1 (OPA1) is required for induction of fatty… read more here.
Keywords: opa1; induced browning; adipose tissue; white adipose ... See more keywords
Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.744838
Abstract: Optic atrophy1 (OPA1) is crucial for inner mitochondrial membrane (IMM) fusion and essential for maintaining crista structure and mitochondrial morphology. Optic atrophy and hearing impairment are the most prevalent clinical features associated with mutations in… read more here.
Keywords: opa1 prevents; cisplatin; opa1; induced ototoxicity ... See more keywords
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.774108
Abstract: Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae… read more here.
Keywords: ca2 homeostasis; mitochondria coupling; opa1; opa1 modulates ... See more keywords
First Description of Inheritance of a Postzygotic OPA1 Mosaic Variant
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030478
Abstract: Optic atrophy 1 (MIM #165500) is caused by pathogenic variants in the gene OPA1 (OPA1 MITOCHONDRIAL DYNAMIN-LIKE GTPase, MIM *605290) and is inherited in an autosomal dominant manner. We describe a 6-year-old male patient with… read more here.
Keywords: optic atrophy; variant; mosaic variant; opa1 ... See more keywords