Characterization of YY1 OPB Peptide for Its Anticancer Activity.
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DOI: 10.2174/1568009618666181031153151
Abstract: The oncoprotein binding (OPB) domain of Yin Yang 1 (YY1) consists of 26 amino acids between G201 and S226, and is involved in YY1 interaction with multiple oncogene products, including MDM2, AKT, EZH2 and E1A.… read more here.
Keywords: activity; opb peptide; opb domain; cancer ... See more keywords
YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins
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DOI: 10.3390/cancers14071611
Abstract: Simple Summary YY1 regulates various cancer-related genes and activates key oncoproteins. In this study, we discovered that the oncoprotein binding (OPB) domain of YY1 is both necessary and stimulatory to its oligomerization. The hydrophobic residues,… read more here.
Keywords: oligomerization; opb domain; yy1; hydrophobic residues ... See more keywords