Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells
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DOI: 10.1002/glia.23567
Abstract: During development or after brain injury, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes to supplement the number of oligodendrocytes. Although mechanisms of OPC differentiation have been extensively examined, the role of epigenetic regulators, such as… read more here.
Keywords: epigenetic regulators; differentiation; differential roles; opc differentiation ... See more keywords
GABAB receptor agonist baclofen promotes central nervous system remyelination
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DOI: 10.1002/glia.24262
Abstract: Promoting remyelination is considered as a potential neurorepair strategy to prevent/limit the development of permanent neurological disability in patients with multiple sclerosis (MS). To this end, a number of clinical trials are investigating the potential… read more here.
Keywords: gabab receptor; opc differentiation; remyelination; agonist baclofen ... See more keywords
Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury
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DOI: 10.3389/fphar.2022.914153
Abstract: The recovery of spinal cord injury (SCI) is closely associated with the obstruction of oligodendrocyte progenitor cell (OPC) differentiation, which ultimately induces the inability to generate newly formed myelin. To address the concern, drug-based methods… read more here.
Keywords: sci; erk1; opc differentiation; clemastine ... See more keywords
High Mobility Group A1 Regulates Transcription Levels of Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor Cells
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DOI: 10.3390/ijms23042236
Abstract: Oligodendrocyte precursor cells (OPCs) serve as progenitor cells of terminally differentiated oligodendrocytes. Past studies have confirmed the importance of epigenetic system in OPC differentiation to oligodendrocytes. High mobility group A1 (HMGA1) is a small non-histone… read more here.
Keywords: hmga1; precursor cells; mrna; opc differentiation ... See more keywords
CLC-2 is a positive modulator of oligodendrocyte precursor cell differentiation and myelination
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DOI: 10.3892/mmr.2018.8439
Abstract: Oligodendrocytes (OLs) are myelin-forming cells that are present within the central nervous system. Impaired oligodendrocyte precursor cell (OPC) differentiation into mature OLs is a major cause of demyelination diseases. Therefore, identifying the underlying molecular mechanisms… read more here.
Keywords: differentiation myelination; clc; differentiation; opc differentiation ... See more keywords