Expanded Potential Stem Cells from Human Embryos Have an Open Chromatin Configuration with Enhanced Trophoblast Differentiation Ability
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204797
Abstract: Human expanded potential stem cells (hEPSC) have been derived from human embryonic stem cells and induced pluripotent stem cells. Here direct derivation of hEPSC from human pre‐implantation embryos is reported. Like the reported hEPSC, the… read more here.
Keywords: potential stem; expanded potential; open chromatin; differentiation ... See more keywords
Non‐Random Distribution of EMS‐Induced Mutations Reveals Preference for Open Chromatin and Expressed Genes in Rice
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202510034
Abstract: Mutagenesis is an effective strategy to generate genetic resources for functional genomics and crop improvement. It is widely accepted that chemical‐induced mutations are randomly distributed across the genome. However, the randomness of such mutations remains… read more here.
Keywords: open chromatin; induced mutations; ems induced; expressed genes ... See more keywords
Pan‐cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4749
Abstract: Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open chromatin regions is lower than that in flanking regions because of the higher accessibility of DNA repair… read more here.
Keywords: regions possible; open chromatin; mutations open; cancer ... See more keywords
Characterization of open chromatin sensitive to actin polymerization and identification of core‐binding factor subunit beta as mechanosensitive nucleocytoplasmic shuttling protein
Sign Up to like & getrecommendations! Published in 2024 at "Cytoskeleton"
DOI: 10.1002/cm.21925
Abstract: Mechanotransduction leads to a variety of biological responses including gene expression, changes in cell shape, migration, tissue development, and immune responses. Dysregulation of mechanotransduction is implicated in the progression of various diseases such as cardiovascular… read more here.
Keywords: mechanosensitive nucleocytoplasmic; open chromatin; nucleocytoplasmic shuttling; core binding ... See more keywords
Using Open Chromatin Enrichment and Network Hi-C (OCEAN-C) to Identify Open Chromatin Interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1597-3_12
Abstract: The open chromatin enrichment and network Hi-C (OCEAN-C) was developed not only for identifying large-scale chromatin structures, including topologically associated domains (TADs) and A/B compartments, but also for globally mapping hubs of open chromatin interactions (HOCIs)… read more here.
Keywords: chromatin interactions; chromatin; network ocean; open chromatin ... See more keywords
HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.06.008
Abstract: In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their "personal regulome" analysis framework reveals… read more here.
Keywords: finally open; hdac inhibitors; accessibility; open chromatin ... See more keywords
Open Chromatin Profiling Identifies Functional Noncoding Risk Variants In Human Ipsc Model of Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.122
Abstract: Abstract Most disease variants lie within poorly-annotated noncoding parts of the genome, and their functional interpretation is challenging. To functionally assess the relevance of noncoding sequences in neuropsychiatric disorders, we hypothesized that disease-relevant noncoding sequences… read more here.
Keywords: risk; noncoding; open chromatin; human ipsc ... See more keywords
33 LANDSCAPE OF ALLELE-SPECIFIC OPEN CHROMATIN IN HUMAN IPSC-DIFFERENTIATED NEURONS AND IT IMPLICATION FOR MENTAL DISORDERS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.034
Abstract: Background Allelic Imbalance of gene Expression (AIE) plays important role during neurodevelopment. However, the underlying mechanism of AIE has not been fully understood. Since chromatin accessibility (openness) has a strong influence on gene transcription, we… read more here.
Keywords: chromatin; open chromatin; specific open; allele specific ... See more keywords
SA97 CHANGES OF OPEN CHROMATIN REGIONS REVEAL STAGE-SPECIFIC TRANSCRIPTIONAL NETWORK DYNAMICS IN HUMAN IPSC-DERIVED NEURONS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.169
Abstract: Background The application of human induced Pluripotent Stem Cells (iPSCs)-differentiated neurons has served as a promising model for gaining insights into the molecular and cellular mechanisms of genetic risk for mental disorders. Multiple factors determine… read more here.
Keywords: chromatin; differentiation; open chromatin; changes open ... See more keywords
Open Sesame: Open Chromatin Regions Shed Light onto Non-coding Risk Variants.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.08.006
Abstract: Human genetics and stem cell biology have advanced neurobiology for neurodevelopmental psychiatric disorders. In this issue of Cell Stem Cell, Forrest et al. (2017) demonstrate that studying the landscape of open chromatin regions in stem cell-derived… read more here.
Keywords: chromatin regions; stem cell; non coding; open chromatin ... See more keywords
How noncoding open chromatin regions shape soybean domestication.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in plant science"
DOI: 10.1016/j.tplants.2021.06.008
Abstract: Open chromatin regions (OCRs), a generally conserved genomic feature amongst plant species, contain noncoding cis-regulatory elements for gene regulation. Wang et al. recently investigated how OCR structures and noncoding regions might have influenced the domestication… read more here.
Keywords: regions shape; domestication; chromatin regions; noncoding open ... See more keywords