Expanded Potential Stem Cells from Human Embryos Have an Open Chromatin Configuration with Enhanced Trophoblast Differentiation Ability
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204797
Abstract: Human expanded potential stem cells (hEPSC) have been derived from human embryonic stem cells and induced pluripotent stem cells. Here direct derivation of hEPSC from human pre‐implantation embryos is reported. Like the reported hEPSC, the… read more here.
Keywords: potential stem; expanded potential; open chromatin; differentiation ... See more keywords
Pan‐cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4749
Abstract: Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open chromatin regions is lower than that in flanking regions because of the higher accessibility of DNA repair… read more here.
Keywords: regions possible; open chromatin; mutations open; cancer ... See more keywords
Using Open Chromatin Enrichment and Network Hi-C (OCEAN-C) to Identify Open Chromatin Interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1597-3_12
Abstract: The open chromatin enrichment and network Hi-C (OCEAN-C) was developed not only for identifying large-scale chromatin structures, including topologically associated domains (TADs) and A/B compartments, but also for globally mapping hubs of open chromatin interactions (HOCIs)… read more here.
Keywords: chromatin interactions; chromatin; network ocean; open chromatin ... See more keywords
HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.06.008
Abstract: In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their "personal regulome" analysis framework reveals… read more here.
Keywords: finally open; hdac inhibitors; accessibility; open chromatin ... See more keywords
Open Chromatin Profiling Identifies Functional Noncoding Risk Variants In Human Ipsc Model of Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.122
Abstract: Abstract Most disease variants lie within poorly-annotated noncoding parts of the genome, and their functional interpretation is challenging. To functionally assess the relevance of noncoding sequences in neuropsychiatric disorders, we hypothesized that disease-relevant noncoding sequences… read more here.
Keywords: risk; noncoding; open chromatin; human ipsc ... See more keywords
33 LANDSCAPE OF ALLELE-SPECIFIC OPEN CHROMATIN IN HUMAN IPSC-DIFFERENTIATED NEURONS AND IT IMPLICATION FOR MENTAL DISORDERS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.034
Abstract: Background Allelic Imbalance of gene Expression (AIE) plays important role during neurodevelopment. However, the underlying mechanism of AIE has not been fully understood. Since chromatin accessibility (openness) has a strong influence on gene transcription, we… read more here.
Keywords: chromatin; open chromatin; specific open; allele specific ... See more keywords
SA97 CHANGES OF OPEN CHROMATIN REGIONS REVEAL STAGE-SPECIFIC TRANSCRIPTIONAL NETWORK DYNAMICS IN HUMAN IPSC-DERIVED NEURONS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.169
Abstract: Background The application of human induced Pluripotent Stem Cells (iPSCs)-differentiated neurons has served as a promising model for gaining insights into the molecular and cellular mechanisms of genetic risk for mental disorders. Multiple factors determine… read more here.
Keywords: chromatin; differentiation; open chromatin; changes open ... See more keywords
Open Sesame: Open Chromatin Regions Shed Light onto Non-coding Risk Variants.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.08.006
Abstract: Human genetics and stem cell biology have advanced neurobiology for neurodevelopmental psychiatric disorders. In this issue of Cell Stem Cell, Forrest et al. (2017) demonstrate that studying the landscape of open chromatin regions in stem cell-derived… read more here.
Keywords: chromatin regions; stem cell; non coding; open chromatin ... See more keywords
How noncoding open chromatin regions shape soybean domestication.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in plant science"
DOI: 10.1016/j.tplants.2021.06.008
Abstract: Open chromatin regions (OCRs), a generally conserved genomic feature amongst plant species, contain noncoding cis-regulatory elements for gene regulation. Wang et al. recently investigated how OCR structures and noncoding regions might have influenced the domestication… read more here.
Keywords: regions shape; domestication; chromatin regions; noncoding open ... See more keywords
Evolution of embryonic cis-regulatory landscapes between divergent Phallusia and Ciona ascidians.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2019.01.003
Abstract: Ascidian species of the Phallusia and Ciona genera are distantly related, their last common ancestor dating several hundred million years ago. Although their genome sequences have extensively diverged since this radiation, Phallusia and Ciona species… read more here.
Keywords: chromatin; chromatin regions; open chromatin; cis regulatory ... See more keywords
Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07451-z
Abstract: During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to identify enhancers involved in the initial events of cardiogenesis, which occurs during the… read more here.
Keywords: heart; chromatin; chromatin regions; expression ... See more keywords