A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport
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DOI: 10.1038/s41467-017-02202-y
Abstract: Neurotransmitter:sodium symporters (NSS), targets of antidepressants and psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na+)-coupled transport. Substrate and Na+ are thought to be transported from the extracellular to intracellular space through an alternating… read more here.
Keywords: mechanism; partially open; transport; sodium ... See more keywords