Novel Insights Into Small Open Reading Frame‐Encoded Micropeptides in Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70093
Abstract: Glioblastoma is the most aggressive type of brain tumor, with a dismal prognosis, highlighting the urgent need for novel biomarkers and therapeutic targets. Recent advances in transcriptomics and proteomics have revealed the critical role of… read more here.
Keywords: open reading; encoded micropeptides; reading frame; small open ... See more keywords
Expression of L1 retrotransposon open reading frame protein 1 (L1ORF1p) in gynecologic cancers.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.06.001
Abstract: LINE-1 (L1) retrotransposons are mobile genetic elements capable of "copy-and-pasting" their own sequences into random genomic loci and one of the proteins it uses to achieve mobility is LINE-1 open reading frame 1 protein (L1ORF1p).… read more here.
Keywords: frame protein; reading frame; l1orf1p expression; expression ... See more keywords
Systematizing the genomic order and relatedness in the open reading frames (ORFs) of the coronaviruses
Sign Up to like & getrecommendations! Published in 2021 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2021.104858
Abstract: The coronaviruses (CoVs), including SARS-CoV-2, the agent of the ongoing deadly CoVID-19 pandemic (Coronavirus disease-2019), represent a highly complex and diverse class of RNA viruses with large genomes, complex gene repertoire, and intricate transcriptional and… read more here.
Keywords: order relatedness; order; genomic order; systematizing genomic ... See more keywords
Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemia/reperfused isolated rat hearts
Sign Up to like & getrecommendations! Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2019.170192
Abstract: The novel peptide dwarf open reading frame (DWORF), highly conserved across species and expressed almost exclusively in cardiac ventricular muscle, may play a role in cardiac physiology and pathophysiology. The effect of direct administration of… read more here.
Keywords: rat hearts; reading frame; effects dworf; dwarf open ... See more keywords
Messenger RNAs with large numbers of upstream open reading frames are translated via leaky scanning and reinitiation in the asexual stages of Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology"
DOI: 10.1017/s0031182020000840
Abstract: Abstract The genome of Plasmodium falciparum has one of the most skewed base-pair compositions of any eukaryote, with an AT content of 80–90%. As start and stop codons are AT-rich, the probability of finding upstream… read more here.
Keywords: open reading; leaky scanning; translation; dorf ... See more keywords
Discovery and Characterization of Actinosynnelassin: An Anti-Pseudomonas fluorescens Lasso Peptide Derived from a Large Precursor Open Reading Frame.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.5c00312
Abstract: Lasso peptides, a unique class of ribosomally synthesized and post-translationally modified peptide (RiPP), are challenging to synthesize chemically, making the discovery of new peptides and their biosynthetic pathways essential. This study reports the discovery and… read more here.
Keywords: discovery characterization; lasso peptide; precursor; actinosynnelassin ... See more keywords
An Integrated Approach for Discovering Noncanonical MHC-I Peptides Encoded by Small Open Reading Frames.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.1c00076
Abstract: MHC-I peptides are a group of important immunopeptides presented by major histocompatibility complex (MHC) on the cell surface for immune recognition. The majority of reported MHC-I peptides are derived from protein coding sequences, and noncanonical… read more here.
Keywords: small open; mhc; noncanonical mhc; approach ... See more keywords
Classification and function of small open reading frames
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.58
Abstract: Small open reading frames (smORFs) of 100 codons or fewer are usually — if arbitrarily — excluded from proteome annotations. Despite this, the genomes of many metazoans, including humans, contain millions of smORFs, some of… read more here.
Keywords: reading frames; small open; biology; function ... See more keywords
A dsRNA virus with filamentous viral particles
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00237-9
Abstract: Viruses with double-stranded RNA genomes form isometric particles or are capsidless. Here we report a double-stranded RNA virus, Colletotrichum camelliae filamentous virus 1 (CcFV-1) isolated from a fungal pathogen, that forms filamentous particles. CcFV-1 has… read more here.
Keywords: double stranded; stranded rna; virus filamentous; filamentous particles ... See more keywords
Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73307-6
Abstract: Upstream open reading frames (uORFs) are present in the 5′-untranslated regions of many eukaryotic mRNAs, and some peptides encoded by these regions play important regulatory roles in controlling main ORF (mORF) translation. We previously developed… read more here.
Keywords: reading frames; animal genomes; upstream open; cpuorfs ... See more keywords
Evolutionary divergence of novel open reading frames in cichlids speciation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-78555-0
Abstract: Novel open reading frames (nORFs) with coding potential may arise from noncoding DNA. Not much is known about their emergence, functional role, fixation in a population or contribution to adaptive radiation. Cichlids fishes exhibit extensive… read more here.
Keywords: reading frames; speciation; novel open; evolutionary divergence ... See more keywords