Quality assurance of craniospinal irradiation in helical tomotherapy using a dose reconstruction tool based on leaf open time
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.70139
Abstract: Abstract Objective The delivery quality assurance (DQA) of craniospinal irradiation (CSI) due to the target length results in no ideal verification devices. Delivery Analysis (DA) could calculate the dose distribution based on the measured multi… read more here.
Keywords: helical tomotherapy; time; open time; quality assurance ... See more keywords
Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24936
Abstract: Increasing evidence suggests that Alzheimer's disease (AD) progression is driven by a vicious cycle of soluble β-amyloid (Aβ)-induced neuronal hyperactivity. Thus, breaking this vicious cycle by suppressing neuronal hyperactivity may represent a logical approach to… read more here.
Keywords: open time; limiting ryr2; mouse model; ryr2 open ... See more keywords
Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation
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DOI: 10.1016/j.celrep.2020.108169
Abstract: SUMMARY Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine… read more here.
Keywords: hyperactivity; open time; neuronal hyperactivity; ryr2 open ... See more keywords