Synthesis of Ring-Opened Analogues of Oxysterol-Binding Protein-Inhibiting Piperidinyl-thiazole Fungicides
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DOI: 10.1055/s-0036-1588473
Abstract: Novel aminoethyl-, aminopropyl-, and aminobutyl-substituted thiazole-4-carboxamides have been prepared which are ring-opened analogues of piperidinyl-thiazole fungicides. Depending of the chain length, completely different synthetic approaches had to be chosen which vary from a Sonogashira coupling… read more here.
Keywords: thiazole fungicides; ring opened; synthesis ring; piperidinyl thiazole ... See more keywords
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F
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DOI: 10.3390/molecules27144419
Abstract: The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell death. However, extensive assessment of Ipom-F as… read more here.
Keywords: synthesis biological; docking studies; opened analogues; biological evaluation ... See more keywords