1,4‐Dihydropyridinebutyrolactone‐derived ring‐opened ester and amide analogs targeting BET bromodomains
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DOI: 10.1002/ardp.202200288
Abstract: Based on a previously reported 1,4‐dihydropyridinebutyrolactone virtual screening hit, nine lactone ring‐opened ester and seven amide analogs were prepared. The analogs were designed to provide interactions with residues at the entrance of the ZA loop… read more here.
Keywords: bet; bet bromodomains; amide analogs; opened ester ... See more keywords