Studies on the Catalytic Promiscuity of Limonene Epoxide Hydrolases in the Non‐hydrolytic Ring Opening of 1,2‐Epoxides
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DOI: 10.1002/cbic.201900694
Abstract: The non‐hydrolytic ring opening of 1,2‐epoxides in the presence of limonene epoxide hydrolases (LEHs) and different nucleophiles has been investigated. Lyophilized, wild‐type LEHs were tested in selected water‐saturated organic solvents in the presence of cyclohexene… read more here.
Keywords: opening epoxides; ring opening; hydrolytic ring; non hydrolytic ... See more keywords
Regioselective ring-opening of epoxides towards Markovnikov alcohols: a metal-free catalytic approach using abnormal N-heterocyclic carbene.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03549a
Abstract: Herein we report the first metal-free regioselective Markovnikov ring-opening of epoxides (selectivity up to 99%) using an abnormal N-heterocyclic carbene (aNHC) to yield secondary alcohols. DFT calculations and X-ray crystallography suggest that the Markovnikov selectivity… read more here.
Keywords: opening epoxides; metal free; abnormal heterocyclic; using abnormal ... See more keywords