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Published in 2020 at "Synthesis"
DOI: 10.1055/s-0040-1706639
Abstract: An unprecedented N-chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n-Bu4NCl as an exogenous nucleophile was identified,…
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Keywords:
ring opening;
opening mechanism;
chlorinative ring;
bicyclization ring ... See more keywords
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Published in 2022 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2022.2144260
Abstract: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible…
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Keywords:
ring opening;
synthesis hydroxyprogesterone;
opening mechanism;
mechanism epoxy ... See more keywords