N-Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Synthesis"
DOI: 10.1055/s-0040-1706639
Abstract: An unprecedented N-chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n-Bu4NCl as an exogenous nucleophile was identified,… read more here.
Keywords: ring opening; opening mechanism; chlorinative ring; bicyclization ring ... See more keywords
Synthesis of 19-hydroxyprogesterone and insights into the ring-opening mechanism of the 6,19-epoxy bridge.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2022.2144260
Abstract: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible… read more here.
Keywords: ring opening; synthesis hydroxyprogesterone; opening mechanism; mechanism epoxy ... See more keywords