Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00338
Abstract: The activation of Homo sapiens Casein lysing protease P (HsClpP) by a chemical or genetic strategy has been proved to be a new potential therapy in acute myeloid leukemia (AML). However, limited efficacy has been… read more here.
Keywords: novel class; ring opening; strategy; opening strategy ... See more keywords
Stereocontrolled Synthesis of Cyclobutylamines Enabled by Lewis Acid-Catalyzed (3 + 2 + 2) Cycloaddition/Ring-Opening Strategy of Bicyclo[1.1.0]butanes with Triazinanes.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c03862
Abstract: Herein, we develop a modular and efficient "cycloaddition/ring-opening" strategy of bicyclo[1.1.0]butanes (BCBs) with triazinanes to provide a series of syn-diastereoselective cyclobutylamines via 2,4-diazabicyclo[4.1.1]octanes (aza-BCOs). The reaction features simple operation, mild reaction conditions, and a broad… read more here.
Keywords: strategy bicyclo; ring opening; bicyclo butanes; opening strategy ... See more keywords