The Role of Osteoprotegerin in Vascular Calcification and Bone Metabolism: The Basis for Developing New Therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "Calcified Tissue International"
DOI: 10.1007/s00223-019-00573-6
Abstract: Osteoporosis (OP) and cardiovascular diseases (CVD) are both important causes of mortality and morbidity in aging patients. There are common mechanisms underlying the regulation of bone remodeling and the development of smooth muscle calcification; a… read more here.
Keywords: opg; vascular calcification; metabolism; calcification ... See more keywords
Discovery of the RANKL/RANK/OPG system
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01175-1
Abstract: Almost a quarter century has passed since discovery of receptor activator of NF-κB ligand (RANKL). This discovery had a major impact on identification of mechanisms regulating osteoclast differentiation and function, establishment of a research field… read more here.
Keywords: rankl rank; opg; system; discovery ... See more keywords
Evaluation of cortical mandibular bone in patients with oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-017-2153-8
Abstract: ObjectivesThe aim of the study was to evaluate the mandible cortical bone changes in patients with oral squamous cell carcinoma (OSCC).Patients and methodsTwenty patients who underwent some mandibular bone removal as part of the treatment… read more here.
Keywords: bone; cell carcinoma; squamous cell; opg ... See more keywords
Roles of SP600125 in expression of JNK, RANKL and OPG in cultured dental follicle cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04745-3
Abstract: ObjectiveTo investigate the expression of C-JNK, RANKL and OPG after SP600125 administration in cultured dental follicle cells (DFCs).MethodsTRAP staining and electron microscope were carried out on day 7 and 9 after coculture of BMMs and… read more here.
Keywords: jnk rankl; opg; jnk; expression jnk ... See more keywords
Impaired bone matrix glycoprotein pattern is associated with increased cardio-metabolic risk profile in patients with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-018-0941-x
Abstract: PurposeOsteopontin (OPN), osteoprotegerin (OPG) and osteocalcin (OC) are matrix glycoproteins which mediate bone mineralization; moreover, their effects on glucose/insulin homeostasis have recently been demonstrated. Higher circulating OPN and OPG levels have been associated with the… read more here.
Keywords: opg; opg levels; bone; type diabetes ... See more keywords
Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105361
Abstract: The OPG/RANKL/RANK pathway is a promising target for the design of therapeutic agents used in the treatment of osteoporosis. E09241 with an N-methylpyridine-chlorofuranformamide structural skeleton was previously identified to decrease bone loss and thus protect… read more here.
Keywords: opg; methylpyridine chlorofuranformamide; induced osteoclastogenesis; rankl induced ... See more keywords
RANK-RANKL signaling upregulates Il-10 mRNA expression in mucosal Candida infection in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104285
Abstract: Osteoprotegerin (OPG) prevents binding of receptor activator of nuclear factor-kappa B ligand (RANKL) to RANK. Recent studies have reported that immune cell RANK-RANKL interactions are critical to the infection process. Candida albicans is an opportunistic… read more here.
Keywords: opg; infection; expression; rank rankl ... See more keywords
Increased Circulating Osteoprotegerin Levels in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis Based on Observational Studies
Sign Up to like & getrecommendations! Published in 2020 at "Immunological Investigations"
DOI: 10.1080/08820139.2019.1710531
Abstract: ABSTRACT Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP).… read more here.
Keywords: opg; opg levels; type diabetes; diabetes mellitus ... See more keywords
Elevated Circulating Osteoprotegerin Levels in the Plasma of Hemodialyzed Patients With Severe Artery Calcification
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutic Apheresis and Dialysis"
DOI: 10.1111/1744-9987.12681
Abstract: We studied the correlations between circulating osteoprotegerin (OPG) level and radial artery calcification (RAC) assessed histologically and carotid artery intima‐media thickness (CCA‐IMT). Moreover, we studied the relationship between OPG levels and all‐cause and cardiovascular (CV)… read more here.
Keywords: opg; cca imt; calcification; presence ... See more keywords
The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1063815
Abstract: With the markedly increased diagnosis and incidence of cancer in the population, tumor bone metastasis has become a frequent event in tumor patients. Healthy bone integrity is maintained by a delicate balance between bone formation… read more here.
Keywords: tumor bone; bone; bone metastasis; opg ... See more keywords
Osteoprotegerin: Relationship to Breast Cancer Risk and Prognosis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00462
Abstract: Osteoprotegerin (OPG) is a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily (TNFRSF11B), that was first characterized and named for its protective role in bone remodeling. In this context, OPG binds to another… read more here.
Keywords: opg; breast; breast cancer; role ... See more keywords