Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila
Sign Up to like & getrecommendations! Published in 2022 at "Horticulture Research"
DOI: 10.1093/hr/uhac099
Abstract: Abstract Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza pumila is an ideal plant model for the study of camptothecin production, with various advantages for studying camptothecin biosynthesis and regulation. The… read more here.
Keywords: biosynthesis; camptothecin biosynthesis; wrky transcription; transcription factors ... See more keywords
OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13377
Abstract: Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. Ophiorrhiza pumila, the herbaceous plant from the Rubiaceae… read more here.
Keywords: camptothecin; pumila; loganic acid; plant ... See more keywords
Genome-wide survey of the GATA gene family in camptothecin-producing plant Ophiorrhiza pumila
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DOI: 10.1186/s12864-022-08484-x
Abstract: Background Ophiorrhiza pumila (Rubiaceae) is capable of producing camptothecin (CPT), one monoterpene indole alkaloid extensively employed in the treatment of multiple cancers. Transcription factors (TFs) GATA are a group of transcription regulators involved in plant… read more here.
Keywords: wide survey; ophiorrhiza pumila; genome wide; survey gata ... See more keywords
Effects of Concentration and Temperature of Nutrient Solution on Growth and Camptothecin Accumulation of Ophiorrhiza pumila
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DOI: 10.3390/plants9060793
Abstract: The medicinal plant, Ophiorrhiza pumila, naturally grows on the floors of humid inland forests in subtropical areas. It accumulates camptothecin (CPT), which is used as an anti-tumor agent, in all organs. We investigated the optimal… read more here.
Keywords: accumulation; nutrient solution; pumila; ophiorrhiza pumila ... See more keywords