The viability of primary hepatocytes is maintained under a low cysteine‐glutathione redox state with a marked elevation in ophthalmic acid production
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.10.017
Abstract: Abstract Extracellular cystine, the oxidized form of cysteine (Cys), is taken up by cells via the cystine transporter xCT. xCT is not expressed in the liver but is induced in primary hepatocytes under conventional cultured… read more here.
Keywords: ophthalmic acid; primary hepatocytes; cysteine; gsh ... See more keywords
Production of Ophthalmic Acid Using Engineered Escherichia coli
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DOI: 10.1128/aem.02806-17
Abstract: ABSTRACT Ophthalmic acid (OA; l-γ-glutamyl-l-2-aminobutyryl-glycine) is an analog of glutathione (GSH; l-γ-glutamyl-l-cysteinyl-glycine) in which the cysteine moiety is replaced by l-2-aminobutyrate. OA is a useful peptide for the pharmaceutical and/or food industries. Herein, we report… read more here.
Keywords: ophthalmic acid; escherichia coli; using engineered; production ... See more keywords