Ophthalmic Drug Discovery in the United States over the past Two Decades
Sign Up to like & getrecommendations! Published in 2020 at "Ophthalmic Epidemiology"
DOI: 10.1080/09286586.2020.1786591
Abstract: ABSTRACT Purpose Pharmaceutical development has slowed since the turn of the century and there has been recent legislation passed that aims to accelerate drug approval. Ophthalmic drug discovery has unique challenges that may benefit from… read more here.
Keywords: drug; drug discovery; drug approvals; ophthalmic drug ... See more keywords
An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adv1661
Abstract: Microneedles directly penetrating into the cornea inevitably cause pain, corneal structure damage, and reduced light transmittance. In this work, a minimally invasive annular microneedle (A-MN) patch was developed avoiding direct puncture into the central cornea… read more here.
Keywords: minimally invasive; ophthalmic drug; drug delivery; mns ... See more keywords
Radiochemistry; A useful tool in the ophthalmic drug discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190530122032
Abstract: Positron Emission Tomography (PET) and Single Photon Emission Computerized Tomography (SPECT) are ultra-sensitive, fully translational and minimally invasive nuclear imaging techniques capable to trace the spatiotemporal distribution of positron (PET) or gamma (SPECT) emitter-labeled molecules… read more here.
Keywords: useful tool; radiochemistry useful; drug; nuclear imaging ... See more keywords
Emulsion and Emulgel-Based Ophthalmic Drug Delivery Systems
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17121504
Abstract: Ophthalmic drug delivery encounters unique challenges due to the anatomical and physiological ocular barriers, necessitating the development of novel drug delivery systems (NDDSs). This review focuses on emerging therapeutic platforms, including nanoemulsions (NEs), microemulsions (MEs),… read more here.
Keywords: emulsifying drug; ophthalmic drug; drug delivery; delivery ... See more keywords
Nanoemulsions as Ophthalmic Drug Delivery Systems
Sign Up to like & getrecommendations! Published in 2021 at "Turkish journal of pharmaceutical sciences"
DOI: 10.4274/tjps.galenos.2020.59319
Abstract: Ophthalmic drug delivery system is one of the most important routes of drug administration, but it is regarded as a challenging attempt encountered by pharmaceutical scientists.1 Most ophthalmic diseases are treated by topical eye drop… read more here.
Keywords: drug delivery; delivery systems; drug; nanoemulsions ophthalmic ... See more keywords
Principles for Management of Extractables and Leachables in Ophthalmic Drug Products.
Sign Up to like & getrecommendations! Published in 2022 at "PDA journal of pharmaceutical science and technology"
DOI: 10.5731/pdajpst.2022.012744
Abstract: Ophthalmic solutions and suspensions have long been classified into a high risk category with respect to concerns over extractables and leachables (E&L), though specific guidance on the management of leachables in these products is generally… read more here.
Keywords: safety; drug products; extractables leachables; ophthalmic drug ... See more keywords