Reverse engineering and formulation by QBD of olopatadine hydrochloride ophthalmic solution
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-017-0312-1
Abstract: Reverse engineering of innovator product’s formulation is a cost-effective strategy for accelerating generic product development. The total market share for olopatadine hydrochloride (OLH) ophthalmic solution used as an antihistamine in US is nearly $230 million dollars.… read more here.
Keywords: ophthalmic solution; olopatadine hydrochloride; formulation; reverse engineering ... See more keywords
In Vitro and In-Eye Comparison of Commercial Pilocarpine Ophthalmic Solution and an Optimized, Reformulated Pilocarpine for Presbyopia Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmology and Therapy"
DOI: 10.1007/s40123-022-00482-2
Abstract: Pilocarpine hydrochloride (pilo) ophthalmic solution has traditionally been used for the treatment of glaucoma, with opportunities to improve the tolerability profile experienced by patients. Pilocarpine hydrochloride ophthalmic solution 1.25% (Vuity™, Allergan, an AbbVie company) was… read more here.
Keywords: formulation; vitro; ophthalmic solution; treatment ... See more keywords
Observational Clinical Investigation Evaluating an Ophthalmic Solution Containing Xanthan Gum and Low Concentration Desonide Phosphate in Dry Eye Disease Treatment
Sign Up to like & getrecommendations! Published in 2024 at "Ophthalmology and Therapy"
DOI: 10.1007/s40123-024-01003-z
Abstract: Patients with dry eye disease (DED) complain of a multitude of symptoms that affect their visual function and quality of life (QoL). This clinical investigation assessed the performance, tolerance, and safety of a novel preservative-free… read more here.
Keywords: ophthalmic solution; treatment; reduction; clinical investigation ... See more keywords
Safety and Efficacy of Lotilaner Ophthalmic Solution (0.25%) in Treating Demodex Blepharitis: Pooled Analysis of Two Pivotal Trials
Sign Up to like & getrecommendations! Published in 2025 at "Ophthalmology and Therapy"
DOI: 10.1007/s40123-024-01089-5
Abstract: Lotilaner ophthalmic solution (0.25%) is the first United States Food and Drug Administration (US FDA)-approved drug for treating Demodex blepharitis. In pivotal trials, it was found to be well tolerated and demonstrated a significant reduction… read more here.
Keywords: demodex blepharitis; lotilaner ophthalmic; ophthalmic solution; group ... See more keywords
Netarsudil Ophthalmic Solution 0.02%: First Global Approval
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0877-7
Abstract: Netarsudil ophthalmic solution 0.02% (hereafter referred to as netarsudil 0.02%) [Rhopressa®] is a Rho-associated protein kinase inhibitor that is thought to lower intraocular pressure (IOP) by increasing aqueous humour outflow through the trabecular meshwork. It… read more here.
Keywords: solution first; ophthalmic solution; netarsudil ophthalmic; first global ... See more keywords
Use of oxymetazoline hydrochloride ophthalmic solution, 0.1% for improved lid symmetry in Graves’ disease
Sign Up to like & getrecommendations! Published in 2024 at "Orbit"
DOI: 10.1080/01676830.2024.2389303
Abstract: ABSTRACT Purpose The purpose of this study is to evaluate the usage of oxymetazoline hydrochloride ophthalmic solution, 0.1% in the treatment of Graves’ disease to improve lid symmetry. Methods Fourteen patients were identified with unilateral… read more here.
Keywords: hydrochloride ophthalmic; graves disease; symmetry; ophthalmic solution ... See more keywords
New resveratrol micelle formulation for ocular delivery: characterization and in vitro/in vivo evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1828909
Abstract: Abstract Many eye diseases, such as corneal wound healing after injury, involve oxidative stress and inflammatory responses; however, many efficient natural antioxidants (e.g. resveratrol) have limited application in ophthalmology due to their poor solubility, low… read more here.
Keywords: resveratrol micelle; ophthalmic solution; sol res; resveratrol ... See more keywords
Tropicamide ophthalmic solution reduces clozapine-induced sialorrhea: a case report
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatry and Clinical Psychopharmacology"
DOI: 10.1080/24750573.2017.1347601
Abstract: ABSTRACT Clozapine-induced sialorrhea (CIS) is a common, treatment-limiting, and stigmatizing side effect. All systemic agents that are used for CIS may increase clozapine side effects such as blood pressure changes, constipation, or arrhythmias or may… read more here.
Keywords: cis; clozapine induced; ophthalmic solution; effect ... See more keywords
Lotilaner Ophthalmic Solution, 0.25%, for the Treatment of Demodex Blepharitis: Results of a Prospective, Randomized, Vehicle-Controlled, Double-Masked, Pivotal Trial (Saturn-1)
Sign Up to like & getrecommendations! Published in 2022 at "Cornea"
DOI: 10.1097/ico.0000000000003097
Abstract: Purpose: The purpose of this study was to evaluate the safety and efficacy of lotilaner ophthalmic solution, 0.25%, compared with vehicle for the treatment of Demodex blepharitis. Methods: In this prospective, randomized, controlled, double-masked, phase… read more here.
Keywords: lotilaner ophthalmic; demodex blepharitis; ophthalmic solution; cure ... See more keywords
Effectiveness and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Treatment-Naive Patients With Primary Open Angle Glaucoma: A Prospective Multicenter Phase IV Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000002605
Abstract: Précis: Omidenepag isopropyl is a selective E-prostanoid subtype 2 (EP2) receptor agonist that lowers intraocular pressure. Omidenepag isopropyl 0.002% ophthalmic solution is effective and safe to use at the first diagnosis of primary open angle… read more here.
Keywords: omidenepag isopropyl; isopropyl 002; glaucoma; ophthalmic solution ... See more keywords
Frequent self-monitoring of intraocular pressure can determine effectiveness of medications in eyes with normal tension glaucoma: A case report
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032478
Abstract: Rationale: It is difficult to follow changes in the intraocular pressure (IOP) in glaucomatous eyes comprehensively because of the limited number of outpatient examinations. We report our findings in a case of normal tension glaucoma… read more here.
Keywords: intraocular pressure; frequent self; ophthalmic solution; tension glaucoma ... See more keywords