Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2016.4703
Abstract: Importance Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of-dose motor fluctuations associated with levodopa therapy in patients with Parkinson disease (PD). Current COMT inhibitors carry a high risk for toxic effects to hepatic… read more here.
Keywords: phase; opicapone; treatment; time ... See more keywords
Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.10.001
Abstract: Introduction: The aim of the study was to clarify the dose response for inhibition of catechol‐O‐methyltransferase (COMT) by opicapone, a third generation COMT inhibitor, after acute and repeated administration to the cynomolgus monkey with pharmacokinetic… read more here.
Keywords: opicapone; inhibition; comt inhibition; repeated administration ... See more keywords
Efficacy and Safety of Opicapone for Motor Fluctuations as an Adjuvant to Levodopa Therapy in Patients with Parkinson’s Disease: A Systematic Review and Meta-Analysis
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DOI: 10.3233/jpd-213057
Abstract: Background: Long-term levodopa administration for treating Parkinson’s disease (PD) may shorten the duration of effect and cause dyskinesias, inducing the need for catechol-O-methyltransferase (COMT) inhibitors as adjuvant therapy. Objective: We provide pooled scientific evidence highlighting… read more here.
Keywords: efficacy safety; time; opicapone; parkinson disease ... See more keywords
Opicapone Improves Global Non-Motor Symptoms Burden in Parkinson’s Disease: An Open-Label Prospective Study
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DOI: 10.3390/brainsci12030383
Abstract: Patients with Parkinson’s disease (PD) can improve some non-motor symptoms (NMS) after starting treatment with opicapone. The aim of this study was to analyze the effectiveness of opicapone on global NMS burden in PD. OPEN-PD… read more here.
Keywords: opicapone; study; non motor; parkinson disease ... See more keywords