Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo.
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DOI: 10.1172/jci.insight.97222
Abstract: W-18 (4-chloro-N-[1-[2-(4-nitrophenyl)ethyl]-2-piperidinylidene]-benzenesulfonamide) and W-15 (4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]-benzenesulfonamide) represent two emerging drugs of abuse chemically related to the potent opioid agonist fentanyl (N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide). Here, we describe the comprehensive pharmacological profiles of W-18 and W-15, as examination of their… read more here.
Keywords: opioid activity; related designer; fentanyl related; designer drugs ... See more keywords