Interactive Mechanisms of Supraspinal Sites of Opioid Analgesic Action: A Festschrift to Dr. Gavril W. Pasternak.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-00961-9
Abstract: Almost a half century of research has elaborated the discoveries of the central mechanisms governing the analgesic responses of opiates, including their receptors, endogenous peptides, genes and their putative spinal and supraspinal sites of action.… read more here.
Keywords: analgesic action; gavril pasternak; opioid analgesic; supraspinal sites ... See more keywords
Health Care Utilization of Opioid Overdose Decedents with No Opioid Analgesic Prescription History
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Urban Health"
DOI: 10.1007/s11524-018-00329-x
Abstract: Opioid overprescribing is a major driver of the current opioid overdose epidemic. However, annual opioid prescribing in the USA dropped from 782 to 640 morphine milligram equivalents per capita between 2010 and 2015, while opioid… read more here.
Keywords: health care; opioid overdose; opioid analgesic; prescription ... See more keywords
Patient‐reported opioid analgesic requirements after elective inguinal hernia repair: A call for procedure‐specific opioid‐administration strategies
Sign Up to like & getrecommendations! Published in 2017 at "Surgery"
DOI: 10.1016/j.surg.2017.06.017
Abstract: Background. A better understanding of the analgesia needs of patients who undergo common operative procedures is necessary as we address the growing opioid public health crisis in the United States. The aim of this study… read more here.
Keywords: hernia repair; elective inguinal; opioid analgesics; opioid analgesic ... See more keywords
What are the advantages of non-opioid analgesic techniques in the management of acute and chronic pain?
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1289176
Abstract: No abstract available Keywords: COX-2 inhibitors; NMDA receptor antagonists; NSAIDs; Non-opioid analgesic; acetaminophen; acute & chronic pain; alpha (α) 2-adrenergic agonists; beta-blockers; cannabinoids; capsaicin; cold laser therapy; electro-analgesia; gabapentanoids; local anesthetics. read more here.
Keywords: chronic pain; opioid analgesic; acute chronic; non opioid ... See more keywords
A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2072731
Abstract: ABSTRACT Introduction Oliceridine is a G protein-selective (biased) agonist at the μ-opioid receptor, with less recruitment of β-arrestin-2, a signaling pathway associated with opioid-related adverse events. Nonclinical evidence showed that oliceridine elicits a rapid systemic… read more here.
Keywords: severe acute; acute pain; oliceridine; pain ... See more keywords
Opioid analgesic use and its sequelae: Opioid and other substance use disorders
Sign Up to like & getrecommendations! Published in 2020 at "Early Intervention in Psychiatry"
DOI: 10.1111/eip.13043
Abstract: While use of opioids is a well‐established risk factor for opioid use disorder (OUD), its association with lifetime use of other addictive substances and the emergence of other lifetime substance use disorders (SUDs) has not… read more here.
Keywords: use disorders; opioid analgesic; use; substance use ... See more keywords
Medical Marijuana and Opioids (MEMO) Study: protocol of a longitudinal cohort study to examine if medical cannabis reduces opioid use among adults with chronic pain
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open"
DOI: 10.1136/bmjopen-2020-043400
Abstract: Introduction In the USA, opioid analgesic use and overdoses have increased dramatically. One rapidly expanding strategy to manage chronic pain in the context of this epidemic is medical cannabis. Cannabis has analgesic effects, but it… read more here.
Keywords: cannabis; use; study; opioid analgesic ... See more keywords
The Opioid Analgesic Reduction Study (OARS) Pilot: A Double-Blind Randomized Multicenter Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JDR clinical and translational research"
DOI: 10.1177/23800844221144031
Abstract: BACKGROUND With addiction rates and opioid deaths increasing, health care providers are obligated to help stem the opioid crisis. As limited studies examine the comparative effectiveness of fixed-dose combination nonopioid analgesia to opioid-containing analgesia, a… read more here.
Keywords: trial; analgesic reduction; opioid analgesic; study ... See more keywords
Payments from drug companies to physicians are associated with higher volume and more expensive opioid analgesic prescribing
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0209383
Abstract: Background While the rise in opioid analgesic prescribing and overdose deaths was multifactorial, financial relationships between opioid drug manufacturers and physicians may be one important factor. Methods Using national data from 2013 to 2015, we… read more here.
Keywords: analgesic prescribing; opioid related; drug; opioid analgesic ... See more keywords
Genome-Wide Association Study Identifies Candidate Loci Associated with Opioid Analgesic Requirements in the Treatment of Cancer Pain
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194692
Abstract: Simple Summary Pain is experienced by ~55% of patients who undergo anti-cancer treatment. However, many genetic factors that are involved in the efficacy of opioid analgesics in the treatment of cancer pain remain unidentified. The… read more here.
Keywords: cancer; cancer pain; treatment; opioid analgesic ... See more keywords
Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030919
Abstract: Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a weak,… read more here.
Keywords: acting opioid; opioid analgesic; opioid receptors; peripherally acting ... See more keywords