Opioid Antagonist Nanodrugs Successfully Attenuate the Severity of Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00079
Abstract: The United States is in the midst of an opioid epidemic that is linked to a number of serious health issues, including an increase in cerebrovascular events, namely, stroke. Chronic prescription opioid use exacerbates the… read more here.
Keywords: opioid antagonist; severity ischemic; opioid antagonists; stroke ... See more keywords
Opioid Antagonists from the Orvinol Series as Potential Reversal Agents for Opioid Overdose
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00464
Abstract: The opioid crisis continues to claim many lives, with a particular issue being the ready availability and use (whether intentional or accidental) of fentanyl and fentanyl analogues. Fentanyl is both potent and longer-acting than naloxone,… read more here.
Keywords: antagonists orvinol; series; reversal; opioid antagonists ... See more keywords
National Systematic Legal Review of State Policies on Emergency Medical Services Licensure Levels' Authority to Administer Opioid Antagonists
Sign Up to like & getrecommendations! Published in 2018 at "Prehospital Emergency Care"
DOI: 10.1080/10903127.2018.1439129
Abstract: Abstract Objective: Previous research conducted in November 2013 found there were a limited number of states and territories in the United States (US) that authorize emergency medical technicians (EMTs) and emergency medical responders (EMRs) to… read more here.
Keywords: state; opioid antagonists; licensure levels; emergency medical ... See more keywords
Hide and Seek: Overcoming the Masking Effect of Opioid Antagonists in Activity-Based Screening Tests.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical chemistry"
DOI: 10.1373/clinchem.2019.309443
Abstract: To the Editor: We previously reported on an alternative activity-based screening method to detect (synthetic) opioids/opiates in blood samples (1) in which μ-opioid receptor activation could be monitored via a split-luciferase system. The ability for… read more here.
Keywords: receptor activation; opioid antagonists; activity based; concentration ... See more keywords
Opioid Antagonists for Pharmacological Treatment of Gambling Disorder: Are they Relevant?
Sign Up to like & getrecommendations! Published in 2018 at "Current Neuropharmacology"
DOI: 10.2174/1570159x15666170718144058
Abstract: Background: To date, no drugs have been approved for gambling disorder. Numerous publications have described the value of opioid antagonists. Indeed, the mesocorticolimbic dopaminergic pathway has been suggested as the underlying cause of reward-seeking behaviour,… read more here.
Keywords: gambling disorder; disorder; opioid antagonists; pharmacological treatment ... See more keywords