Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00512
Abstract: Venom-derived compounds are of broad interest in neuropharmacology and drug development. α-Conotoxins are small disulfide-containing peptides from Conus snails that target nicotinic acetylcholine receptors (nAChRs) and are in clinical development for non-opioid-based treatment of intractable… read more here.
Keywords: selective penicillamine; penicillamine substitution; opioid based; development ... See more keywords
Single-Center Retrospective Comparison of Opioid-Based and Multimodal Analgesic Regimens in Adult Cardiac Surgery.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2023.03.001
Abstract: OBJECTIVES To compare the outcomes of 2 multimodal analgesic regimens with an opioid-based one. DESIGN A 2-stage, retrospective study. SETTING A large tertiary-care facility. PARTICIPANTS Adult cardiac surgical patients. INTERVENTIONS Patients received one of three… read more here.
Keywords: adult cardiac; opioid based; multimodal analgesic; multimodal regimen ... See more keywords
Cannabis as a Substitute for Opioid-Based Pain Medication: Patient Self-Report
Sign Up to like & getrecommendations! Published in 2017 at "Cannabis and Cannabinoid Research"
DOI: 10.1089/can.2017.0012
Abstract: Abstract Introduction: Prescription drug overdoses are the leading cause of accidental death in the United States. Alternatives to opioids for the treatment of pain are necessary to address this issue. Cannabis can be an effective… read more here.
Keywords: cannabis; based pain; medication; opioid based ... See more keywords
A Comparison of Patient Outcomes Using Multimodal Analgesia Versus Opioid-Based Pain Management in Total Joint Arthroplasty
Sign Up to like & getrecommendations! Published in 2021 at "Orthopaedic Nursing"
DOI: 10.1097/nor.0000000000000807
Abstract: Multimodal analgesia (MMA) pain management following total joint arthroplasty (TJA) is gaining momentum as a best practice. Many forces in healthcare are coming together challenging orthopaedic teams to reevaluate postoperative pain management following surgery including… read more here.
Keywords: opioid based; based pain; pain management; management ... See more keywords
Effect of three opioid-based analgesic protocols on the perioperative autonomic-mediated cardiovascular response in sheep
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DOI: 10.1177/0023677218815203
Abstract: Few reports evaluate the clinical effects of opioids in sheep during experimental surgical procedures. Catecholamine-mediated haemodynamic changes resulting from surgical noxious stimulation are blunted by opioids. The aim of this study was to evaluate the… read more here.
Keywords: group; map; opioid based; sheep ... See more keywords
Comparing Clinical Efficacy of Non-Opioid and Opioid-Based Analgesia Protocols [Letter]
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pain Research"
DOI: 10.2147/jpr.s410646
Abstract: In a single-center, randomized, non-inferiority trial including 80 patients who underwent robot-assisted radical prostatectomy, Lee et al 1 compared clinical efficacy of a non-opioid multimodal analgesia (NOMA) protocol with opioid-based patient-controlled analgesia (PCA). They showed… read more here.
Keywords: analgesia; opioid based; non opioid; clinical efficacy ... See more keywords
Opioid-Free Anaesthesia Improves Anaesthesia Recovery When Compared With That Of Opioid-Based Anaesthesia. Systematic Review And Meta-Analysis Of Clinical Trials.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220907155612
Abstract: Introduction Opioid free anesthesia (OFA) is a relatively new technique that has been questioned due to the lack of evidence regarding its benefit-risk balance. Methods Four international databases were searched for clinical trials comparing OFA… read more here.
Keywords: ofa; clinical trials; ci95; opioid free ... See more keywords