The intergenerational persistence of opioid dependence: Evidence from administrative data
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DOI: 10.1002/hec.4589
Abstract: Abstract To address the opioid crisis, it is crucial to understand its origins. We provide descriptive evidence for the intergenerational persistence of opioid dependence. Our analysis is based on administrative data covering the universe of… read more here.
Keywords: administrative data; persistence opioid; opioid dependence; intergenerational persistence ... See more keywords
Review of Case Narratives from Fatal Overdoses Associated with Injectable Naltrexone for Opioid Dependence
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DOI: 10.1007/s40264-018-0653-3
Abstract: IntroductionAn extended-release injectable naltrexone suspension (Vivitrol®) was approved in USA in 2010 for the prevention of relapse to opioid dependence. Concerns, raised at the time of approval, about rebound overdose risk following the last dose,… read more here.
Keywords: fatal overdoses; case narratives; injectable naltrexone; case ... See more keywords
Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans
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DOI: 10.1016/j.biopsych.2017.12.016
Abstract: BACKGROUND Opioid dependence (OD) is at epidemic levels in the United States. Genetic studies can provide insight into its biology. METHODS We completed an OD genome-wide association study in 3058 opioid-exposed European Americans, 1290 of… read more here.
Keywords: genome wide; study; opioid dependence; rgma ... See more keywords
Initial Results From An Opioid Dependence Whole Exome Sequencing Study
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DOI: 10.1016/j.euroneuro.2017.06.056
Abstract: Abstract It is well known that the risk of opioid dependence (OD) is genetically influenced. Several GWAS, including ours, have succeeded at identifying common risk variants for OD. We undertook the present whole exome sequence… read more here.
Keywords: risk; study; opioid dependence; whole exome ... See more keywords
Current and emerging pharmacotherapies for opioid dependence treatments in adults: a comprehensive update
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DOI: 10.1080/14656566.2022.2140039
Abstract: ABSTRACT Introduction Opioid use disorder (OUD) is characterized by compulsive opioid seeking and taking, intense drug craving, and intake of opioids despite negative consequences. The prevalence of OUDs has now reached an all-time high, in… read more here.
Keywords: emerging pharmacotherapies; pharmacotherapies opioid; opioid dependence; opioid ... See more keywords
Opioid Dependence and Overdose After Surgery
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DOI: 10.1097/sla.0000000000005546
Abstract: Objective: To determine: (1) incidence of “opioid never events” (ONEs), defined as the development of opioid dependence or overdose in an opioid-naive surgical patient who is prescribed opioids postoperatively and (2) risk factors predicting ONEs.… read more here.
Keywords: naive surgical; surgery; opioid dependence; opioid naive ... See more keywords
Time‐dependent neuronal changes associated with craving in opioid dependence: an fMRI study
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DOI: 10.1111/adb.12554
Abstract: Relapse after initially successful treatment is a significant problem facing the treatment of opioid dependence. Evidence suggests craving elicited by re‐exposure to drug cues may precipitate relapse. Attempts to identify neural biomarkers of cue‐elicited craving… read more here.
Keywords: drug cue; opioid dependence; cue; time ... See more keywords
Barriers to access to opioid medicines for patients with opioid dependence: a review of legislation and regulations in eleven central and eastern European countries
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DOI: 10.1111/add.13755
Abstract: BACKGROUND AND AIMS Barriers linked to drug control systems are considered to contribute to inequitable access to controlled medicines, leaving millions of people in pain and suffering. Most studies focus on access to opioids for… read more here.
Keywords: legislation regulations; legislation; patients opioid; opioid dependence ... See more keywords
What are the characteristics of vitamin D metabolism in opioid dependence? An exploratory longitudinal study in Australian primary care
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DOI: 10.1136/bmjopen-2017-016806
Abstract: Objective Compare vitamin D levels in opioid dependence and control population and adjust for relevant confounding effects. Nuclear hormone receptors (including the vitamin D receptor) have been shown to be key transducers and regulators of… read more here.
Keywords: dependence; age; primary care; control ... See more keywords
Interrelationship of Opioid Dependence, Impaired Impulse Control, and Depressive Symptoms: An Open-Label Cross-Sectional Study of Patients in Maintenance Therapy
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DOI: 10.1159/000494697
Abstract: Objective: A growing number of studies indicate increased impulsivity in patients with opioid dependence (OD). However, few studies exclude concomitant drug use and consider depression as a comorbidity, both of which can bias results. Aim:… read more here.
Keywords: cross sectional; opioid dependence; maintenance therapy; impulsivity ... See more keywords
Association of Testosterone Levels and Steroid 5-Alpha-Reductase 2 Polymorphisms with Opioid Craving
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DOI: 10.1159/000508681
Abstract: Background/Aims: Opioid dependence is a severe disease which is associated with a high risk of relapse, even in cases of successful withdrawal therapy. Studies have shown alterations of the hypothalamic-pituitary-gonadal axis in opioid-dependent patients, such… read more here.
Keywords: serum levels; testosterone serum; steroid alpha; opioid dependence ... See more keywords