PEG vs. sennosides for opioid-induced constipation in cancer care
Sign Up to like & getrecommendations! Published in 2019 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-019-04944-5
Abstract: Purpose This randomized double-blind, double-dummy, 2-treatment, 2-period crossover study aimed to compare the efficacy and tolerability of polyethylene glycol (PEG) and sennosides in ambulatory cancer patients with opioid-induced constipation. Methods Outpatients ≥ 18 years old with cancer,… read more here.
Keywords: peg sennosides; induced constipation; treatment; opioid induced ... See more keywords
Naldemedine: A Review in Opioid-Induced Constipation
Sign Up to like & getrecommendations! Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01160-7
Abstract: Naldemedine [Symproic® (Japan; USA); Rizmoic® (EU)], an orally available peripherally acting μ-opioid receptor antagonist (PAMORA), is approved in several countries for the treatment of opioid-induced constipation. In phase III trials, naldemedine was more effective than… read more here.
Keywords: induced constipation; cancer pain; naldemedine; opioid induced ... See more keywords
JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113644
Abstract: Epigenetic mechanisms play important roles in the neurobiology of substance use disorder. In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation readers, have been found to regulate cocaine conditioned behaviors, but… read more here.
Keywords: place preference; jq1; conditioned place; opioid induced ... See more keywords
Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2018.12.023
Abstract: BACKGROUND Opioids are potent painkillers but come with serious adverse effects ranging from addiction to potentially lethal respiratory depression. A variety of drugs with separate mechanisms of action are available to prevent or reverse opioid-induced… read more here.
Keywords: induced respiratory; reversal; opioid induced; respiratory depression ... See more keywords
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173169
Abstract: Chronic opioids treatment is impeded by the development of analgesic tolerance and opioid-induced hyperalgesia. Recent studies have shown that multi-functional opioid compounds produce analgesic activities with limited side effects. We developed a novel multi-functional peptide… read more here.
Keywords: tolerance; multi functional; functional opioid; opioid induced ... See more keywords
Patient-Reported Outcomes of Opioid-Induced Constipation as Identified Through Social Media
Sign Up to like & getrecommendations! Published in 2017 at "Value in Health"
DOI: 10.1016/j.jval.2017.08.1447
Abstract: Opioid-induced constipation (OIC) is the most common adverse effect associated with prolonged use of opioids; it has been estimated that between 40% and 95% of patients develop OIC (Kumar et al, 2014). OIC is persistent,… read more here.
Keywords: reported outcomes; induced constipation; opioid induced; outcomes opioid ... See more keywords
Aquaporin-4 deletion attenuates opioid-induced addictive behaviours associated with dopamine levels in nucleus accumbens
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.108986
Abstract: There is a lack of safe and effective non-opioid medications for the treatment of opioid addiction. Aquaporin-4 (AQP4), a water channel protein expressed in astrocytes, regulates the progression of neurological diseases. Our previous work demonstrated… read more here.
Keywords: dopamine; mice; opioid induced; opioid addiction ... See more keywords
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02185
Abstract: Opioid-induced constipation (OIC) is a common adverse effect of opioid analgesics. Peripherally acting μ opioid receptor antagonists (PAMORAs) can be applied in the treatment of OIC without compromising the analgesic effects. NAP, a 6β-N-4-pyridyl-substituted naltrexamine… read more here.
Keywords: induced constipation; opioid receptor; opioid induced; opioid ... See more keywords
Methylnaltrexone bromide for the treatment of opioid-induced constipation
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2018.1491549
Abstract: ABSTRACT Introduction: The extensive and alarming use of opioids for pain management in patients with chronic pain receiving palliative care is associated with non-tolerable gastrointestinal (GI) adverse effects. Opioid-induced constipation (OIC) is the most common… read more here.
Keywords: methylnaltrexone bromide; induced constipation; treatment; opioid induced ... See more keywords
An update on the use of pharmacotherapy for opioid-induced bowel dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2161883
Abstract: ABSTRACT Introduction With the growing rate of aging and the incidence of chronic diseases, there has been an upsurge in opioid prescription and abuse worldwide. This has been associated with increased reports of opioid-related adverse… read more here.
Keywords: opioid induced; bowel dysfunction; induced bowel; pharmacotherapy ... See more keywords
Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001629
Abstract: Naldemedine improves opioid-induced constipation in a timely manner in patients using opioids for noncancer pain; most experienced spontaneous bowel movement within 24 hours of treatment. read more here.
Keywords: induced constipation; treatment; noncancer pain; onset action ... See more keywords