μ‐opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Communications"
DOI: 10.1002/cac2.12408
Abstract: μ‐opioid receptor agonists (MORAs) are indispensable for analgesia in bladder cancer (BC) patients, both during surgery and for chronic pain treatment. Whether MORAs affect BC progression and metastasis remains largely unknown. This study focused on… read more here.
Keywords: circulating tumor; bladder cancer; cancer; opioid receptor ... See more keywords
Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100029
Abstract: The synthesis of 5‐formyl‐6‐aryl‐6H‐indolo[3,2,1‐de][1,5] naphthyridine‐2‐carboxylates by reaction between 1‐formyl‐9H‐β‐carbolines and cinnamaldehydes in the presence of pyrrolidine in water with microwave irradiation is described. Pharmacophoric modification of the formyl group offered several new fused β‐carboline derivatives,… read more here.
Keywords: opioid receptor; synthesis assessment; carboline derivatives; assessment fused ... See more keywords
Investigation of the μ and κ-opioid receptor activation by eight new synthetic opioids using the [35 S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520 and U-48800.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3238
Abstract: In 2009 new synthetic opioids appeared on the new psychoactive substances market. This class of new psychoactive substances generally poses a health risk due to the high affinity and potency of most of these compounds… read more here.
Keywords: opioid receptor; synthetic opioids; using gtp; group ... See more keywords
Mu and delta opioid receptor knockout mice show increased colonic sensitivity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pain"
DOI: 10.1002/ejp.965
Abstract: Opiates act through opioid receptors to diminish pain. Here, we investigated whether mu (MOR) and delta (DOR) receptor endogenous activity assessed in the whole mouse body or in particular at peripheral receptors on primary nociceptive… read more here.
Keywords: opioid receptor; knockout mice; delta opioid; receptor ... See more keywords
Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24640
Abstract: Heroin, a mu agonist, acts through the mu opioid receptor. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, creating an array of splice variants that are conserved from rodent to humans. Increasing evidence… read more here.
Keywords: opioid receptor; heroin abusers; heroin; oprm1 splice ... See more keywords
Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_58
Abstract: The functional diversity of primary afferent neurons of the dorsal root ganglia (DRG) generates a variety of qualitatively and quantitatively distinct somatosensory experiences, from shooting pain to pleasant touch. In recent years, the identification of… read more here.
Keywords: opioid receptor; somatosensory; primary afferent; dor ... See more keywords
Evidence and Function Relevance of Native DOR-MOR Heteromers.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_112
Abstract: Opioid receptors are the sites of action for morphine and most other clinically used opioid drugs. Abundant evidence now demonstrates that different opioid receptor types can physically associate to form heteromers. Owing to their constituent… read more here.
Keywords: evidence function; opioid receptor; evidence; dor ... See more keywords
Antinociceptive Effects of Kappa-Opioid Receptor Agonists.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_430
Abstract: Preclinical models that assess "pain" in rodents typically measure increases in behaviors produced by a "pain stimulus." A large literature exists showing that kappa opioid receptor (KOR) agonists can decrease these "pain-stimulated behaviors" following many… read more here.
Keywords: kor agonists; opioid receptor; pain; kappa opioid ... See more keywords
Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_433
Abstract: This chapter provides a general introduction to the dynorphins (DYNs)/kappa opioid receptor (KOR) system, including DYN peptides, neuroanatomy of the DYNs/KOR system, cellular signaling, and in vivo behavioral effects of KOR activation and inhibition. It… read more here.
Keywords: opioid receptor; system; fundamentals dynorphins; dynorphins kappa ... See more keywords
Monitoring Opioid Receptor Interaction in Living Cells by Bioluminescence Resonance Energy Transfer (BRET).
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0884-5_4
Abstract: Bioluminescence resonance energy transfer (BRET ) is a natural phenomenon that has been successfully applied for the study of protein-protein interactions, including opioid receptor oligomers. The discovery of opioid receptor homomers and heteromers has brought… read more here.
Keywords: energy transfer; opioid receptor; resonance energy; receptor ... See more keywords
Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03595-8
Abstract: μ-opioid receptor (MOR) is a class of opioid receptors that is critical for analgesia, reward, and euphoria. MOR is distributed in various brain regions, including the hippocampus, where traditionally, it is believed to be localized… read more here.
Keywords: opioid receptor; hippocampus; mor; receptor mor ... See more keywords