Delta Opioid Receptors: Learning and Motivation.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_89
Abstract: Delta opioid receptor (DOR) displays a unique, highly conserved, structure and an original pattern of distribution in the central nervous system, pointing to a distinct and specific functional role among opioid peptide receptors. Over the… read more here.
Keywords: receptors learning; pharmacology; opioid receptors; delta opioid ... See more keywords
Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06118-4
Abstract: Emerging evidence has implicated the endogenous opioid system in mediating ketamine's antidepressant activity in subjects with major depressive disorder. To date, mu opioid receptors have been suggested as the primary opioid receptor of interest. However,… read more here.
Keywords: effects ketamine; kappa opioid; opioid receptors; swim test ... See more keywords
Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3916-6
Abstract: Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg),… read more here.
Keywords: reperfusion injury; heart; endogenous agonists; opioid receptors ... See more keywords
Continuous Normobaric Hypoxia Improved Cardiac Bioenergetics after Ischemia/Reperfusion: Role of Opioid Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04814-9
Abstract: We analyzed the role of opioid receptors in the conditioning effect of continuous normobaric hypoxia on bioenergetics of the heart subjected to ischemia/reperfusion injury. Male Wistar rats were adapted to a 21-day continuous normobaric hypoxia… read more here.
Keywords: normobaric hypoxia; reperfusion; opioid receptors; ischemia reperfusion ... See more keywords
Some Aspects of Investigation of the Central Mechanism of Antinociceptive Effect of a New Analgetic from the Hexaazaisowurtzitane Group.
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DOI: 10.1007/s10517-021-05148-w
Abstract: Possible involvement of μ1- and κ-opioid receptors and cannabinoid type 1 receptors (CB1) into the mechanism of analgesic activity of the experimental drug product "Thiowurtzine, (capsule 120 mg)" synthesized on the basis of active pharmaceutical… read more here.
Keywords: mechanism; aspects investigation; effect; opioid receptors ... See more keywords
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1607-1
Abstract: Neuropathic pain is a chronic condition triggered by lesions to the somatosensory nervous system in which pain stimuli occur spontaneously or as pathologically amplified responses. In this scenario, the exchange of signaling molecules throughout cell-to-cell… read more here.
Keywords: model neuropathic; neuropathic pain; opioid receptors; connexin ... See more keywords
Paced mating increases the expression of μ opioid receptors in the ventromedial hypothalamus of male rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.11.027
Abstract: Abstract Paced mating induces a positive affective state which is blocked by naloxone, an opioid antagonist. Opioids are released in the medial preoptic area (mPOA) and other brain regions during sexual behavior and &mgr; opioid… read more here.
Keywords: ventromedial hypothalamus; paced mating; expression mor; opioid receptors ... See more keywords
Antagonists Pharmacologically Chaperone Opioid Receptors
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DOI: 10.1016/j.bpj.2019.11.328
Abstract: More than 100 people die daily in the United States from opioid-related drug overdoses. µ-Opioid receptor (MOR) antagonists, such as naltrexone (Ntx) and naloxone, partially suppress overdose effects, but also induce supersensitivity to MOR activation.… read more here.
Keywords: antagonists pharmacologically; mor; opioid receptors; eres levels ... See more keywords
Rubiscolin-6 activates opioid receptors to enhance glucose uptake in skeletal muscle.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food and drug analysis"
DOI: 10.1016/j.jfda.2018.06.012
Abstract: Rubiscolin-6 is an opioid peptide derived from plant ribulose bisphosphate carboxylase/oxygenase (Rubisco). It has been demonstrated that opioid receptors could control glucose homeostasis in skeletal muscle independent of insulin action. Therefore, Rubiscolin-6 may be involved… read more here.
Keywords: skeletal muscle; uptake skeletal; rubiscolin; glucose uptake ... See more keywords
Agonist binding of human mu opioid receptors expressed in the yeast Pichia pastoris: Effect of cholesterol complementation
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104588
Abstract: This study compared pharmacological profiles between human mu opioid receptors (hMOR) overexpressed in the SH-SY5Y neuroblastoma cell line (SH-hMOR) and the methylotrophic yeast Pichia pastoris (Pp-hMOR). Affinity determinations were performed by direct binding with the… read more here.
Keywords: pastoris; cholesterol; human opioid; yeast pichia ... See more keywords
Effects of mu opioid receptors in paraventricular nucleus on ejaculation through mediating sympathetic nerve system activity
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107709
Abstract: To investigate the roles of mu opioid receptors (MORs) in paraventricular nucleus of the hypothalamus (PVN) on ejaculation and its underlying mechanism in the rats, we performed copulation behavioral testing and acute experiments. During the… read more here.
Keywords: paraventricular nucleus; ejaculation; effects opioid; opioid receptors ... See more keywords