Oxycodone injections not paired with conditioned place preference have little effect on the hippocampal opioid system in female and male rats
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DOI: 10.1002/syn.22182
Abstract: Oxycodone (Oxy) conditioned place preference (CPP) in Sprague Dawley rats results in sex‐specific alterations in hippocampal opioid circuits in a manner that facilitates opioid‐associative learning processes, particularly in females. Here, we examined if Oxy (3… read more here.
Keywords: conditioned place; opioid system; place preference; hippocampal opioid ... See more keywords
Acute Delta 9‐tetrahydrocannabinol administration differentially alters the hippocampal opioid system in adult female and male rats
Sign Up to like & getrecommendations! Published in 2021 at "Synapse"
DOI: 10.1002/syn.22218
Abstract: Our prior studies demonstrated that the rat hippocampal opioid system can undergo sex‐specific adaptations to external stimuli that can influence opioid‐associated learning processes. This opioid system extensively overlaps with the cannabinoid system. Moreover, acute administration… read more here.
Keywords: acute thc; system; opioid system; adult female ... See more keywords
Evidence for the involvement of opioid system in the antidepressant-like effect of ascorbic acid
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1446-4
Abstract: Considering the involvement of the opioid system in major depressive disorder (MDD), mainly concerning refractory MDD, and the evidence that ascorbic acid may exert a beneficial effect for the treatment of this disorder, this study… read more here.
Keywords: opioid system; ascorbic acid; effect; acid ... See more keywords
Endogenous opioid system: a promising target for future smoking cessation medications
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DOI: 10.1007/s00213-017-4582-0
Abstract: BackgroundNicotine addiction continues to be a health challenge across the world. Despite several approved medications, smokers continue to relapse. Several human and animal studies have evaluated the role of the endogenous opioid system as a… read more here.
Keywords: cessation medications; endogenous opioid; opioid system; smoking cessation ... See more keywords
Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.03.015
Abstract: HighlightsSeverity of post‐mTBI deficits correlates with endogenous opioid system activity.Increased opioid tone protects against mTBI‐induced memory deficits.Naloxone impairs memory and exacerbates depressive‐like behavior only in HA mice.mTBI strongly induces depressive‐like behavior in LA mice Abstract… read more here.
Keywords: brain injury; brain; opioid system; traumatic brain ... See more keywords
Endogenous opioid system in addiction and addiction-related behaviors
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2016.12.002
Abstract: Since the discovery and verification of the components of the endogenous opioid system in the 1970s, consisting of the mu, kappa, and delta-opioid receptors, and the cognate ligands β-endorphin, the enkephalins, and the dynorphins, a… read more here.
Keywords: addiction; addiction addiction; opioid system; system addiction ... See more keywords
Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2020.108025
Abstract: Historically, the roots of alcoholism have been linked to either environment or heredity. However, the interaction between these factors is still largely unexplored. The evidence supports a link between alcohol consumption and the endogenous opioid… read more here.
Keywords: expression rats; genes expression; opioid system; endogenous opioid ... See more keywords
P.127 Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2019.09.181
Abstract: This abstract is financially supported by an educational grant from the Strategic Partnership Programme Grant from Science Foundation Ireland and Alkermes, Inc. (14/SPP/B3051). read more here.
Keywords: opioid system; following acute; 127 alterations; central opioid ... See more keywords
Impact of the opioid system on the reproductive axis.
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DOI: 10.1016/j.fertnstert.2017.06.009
Abstract: Endogenous opioids, first described more than 40 years ago, have long been recognized for their main role as important neuromodulators within the central nervous system. More recently endogenous opioids and their receptor have been identified in… read more here.
Keywords: system; endogenous opioids; nervous system; central nervous ... See more keywords
Opioid Peptides and Their Receptors in Chickens: Structure, Functionality, and Tissue Distribution
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DOI: 10.1016/j.peptides.2020.170307
Abstract: {Al-Hasani, 2011 #72} Opioid peptides, derived from PENK, POMC, PDYN and PNOC precursors, together with their receptors (DOR, MOR, KOR and ORL1), constitute the opioid system and are suggested to participate in multiple physiological/pathological processes… read more here.
Keywords: opioid system; functionality tissue; system; opioid peptides ... See more keywords
Role for kappa-opioid system in stress-induced cocaine use uncovered with PET
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0512-7
Abstract: 1. Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenomewide association studies. Genome Biol. 2014;15:R31. 2. Zheng SC, Breeze CE, Beck S, Teschendorff AE. Identification of differentially methylated cell types in epigenome-wide… read more here.
Keywords: science; spatial transcriptomics; opioid system; role kappa ... See more keywords