Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010015
Abstract: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder characterized by progressive weakness and degeneration of specific muscles. OPMD is due to extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1). Aggregation of… read more here.
Keywords: opmd; muscle; activity; muscular dystrophy ... See more keywords
Swallowing, Chewing and Speaking: Frequently Impaired in Oculopharyngeal Muscular Dystrophy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuromuscular diseases"
DOI: 10.3233/jad-200511
Abstract: BACKGROUND Oculopharyngeal muscular dystrophy (OPMD) is a late onset progressive neuromuscular disorder. Although dysphagia is a pivotal sign in OPMD it is still not completely understood. OBJECTIVE The aim of this study was to systematically… read more here.
Keywords: opmd; swallowing chewing; muscular dystrophy; oculopharyngeal muscular ... See more keywords