Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27571
Abstract: Liver biopsy is the current reliable way of evaluating liver fibrosis. However, no specific sera biomarker could be applied in clinical diagnosis. As the pivotal role of osteopontin (OPN) reported in numerous liver diseases, thrombin‐cleaved… read more here.
Keywords: liver fibrosis; thr opn; opn;
Plasma osteopontin levels, but not its myocardial expression, reflect heart failure severity in recently diagnosed dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2019 at "Herz"
DOI: 10.1007/s00059-019-4829-0
Abstract: BackgroundElevated levels of the extracellular matrix glycoprotein osteopontin (OPN) may be detected in both myocardium and plasma under various pathological conditions affecting the heart. Several studies demonstrated increased plasma OPN levels in patients with heart… read more here.
Keywords: dcm; plasma; heart; opn expression ... See more keywords
Can urine osteopontin levels, which may be correlated with nutrition intake and body composition, be used as a new biomarker in the diagnosis of nephrolithiasis?
Sign Up to like & getrecommendations! Published in 2018 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2018.08.001
Abstract: BACKGROUND AND AIM The nephrolithiasis has a multifactorial etiology resulting from the interaction of metabolic, genetic and environmental factors. Parameters such as nutrition and urinary osteopontin (OPN) level may affect kidney stone formation. The purpose… read more here.
Keywords: urinary opn; nephrolithiasis; opn levels; opn ... See more keywords
Optic perineuritis: A Canadian case series and literature review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2021.120035
Abstract: BACKGROUND Optic perineuritis (OPN) is a rare orbital inflammatory disorder that primarily involves the optic nerve sheath (ONS). This study aimed to describe the clinical features of idiopathic OPN as well as OPN secondary to… read more here.
Keywords: optic perineuritis; case series; case; canadian case ... See more keywords
The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31421-6
Abstract: Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues. OPN induces stemness by interacting with CD44, but the functional relevance of OPN-mediated interferon (IFN) signaling and hepatitis C virus… read more here.
Keywords: epcam cd44; ifn signaling; hcv replication; opn ... See more keywords
FC 061OSTEOPONTIN AND ITS ASSOCIATION WITH ADVERSE EVENTS IN THE GERMAN CHRONIC KIDNEY DISEASE STUDY
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab144.004
Abstract: Osteopontin (OPN) is synthesized in the thick ascending limb of Henle’s loop and in the distal tubule. Numerous studies have shown that OPN mRNA and protein expression is increased in animal models of many different… read more here.
Keywords: kidney events; opn; kidney; kidney disease ... See more keywords
Bovine seminal plasma osteopontin: Structural modelling, recombinant expression and its relationship with semen quality.
Sign Up to like & getrecommendations! Published in 2020 at "Andrologia"
DOI: 10.1111/and.13905
Abstract: Osteopontin (OPN) is a multifunctional phosphoprotein that has been linked to fertility in bulls. However, the exact mechanism by which OPN contributes to fertilisation is yet unknown. The biotechnological use of OPN in bovine reproduction… read more here.
Keywords: structural modelling; seminal plasma; recombinant expression; opn ... See more keywords
Plasma osteopontin versus intima media thickness of the common carotid arteries in well-characterised patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2021 at "Lupus"
DOI: 10.1177/09612033211013898
Abstract: Objective The progress of accelerated atherosclerosis in systemic lupus erythematosus (SLE) is incompletely understood. Circulating osteopontin (OPN) is increased in autoimmune conditions, e.g. SLE, and its serum concentration was recently reported to associate with subclinical… read more here.
Keywords: sle; carotid arteries; intima media; media thickness ... See more keywords
Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1
Sign Up to like & getrecommendations! Published in 2018 at "Cell Transplantation"
DOI: 10.1177/0963689718756070
Abstract: Osteopontin (OPN), expressed by various immune cells, plays a critical role in leukocyte migration. Although OPN was found to selectively induce the expression of proinflammatory chemokines, the molecular mechanisms that control OPN gene expression and… read more here.
Keywords: production; kinase; migration; mcp ... See more keywords
Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury Via Stimulation of Pulmonary Neutrophil Accumulation.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019000972
Abstract: Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusionrelated fatalities and is characterized by the onset of acute respiratory distress within 6 hours upon blood transfusion. Specific therapies are unavailable. Pre-existing… read more here.
Keywords: related acute; transfusion related; opn; trali ... See more keywords
Osteopontin in the host response to Leishmania amazonensis
Sign Up to like & getrecommendations! Published in 2019 at "BMC Microbiology"
DOI: 10.1186/s12866-019-1404-z
Abstract: BackgroundLeishmania (L.) spp are intracellular eukaryotic parasites responsible for cutaneous or visceral leishmaniasis, replicating predominantly in macrophages (MF). In C57BL/6 mice virulence with L. amazonensis has been associated with inhibition of Th1 immune responses and… read more here.
Keywords: response amazonensis; amazonensis; response; host response ... See more keywords