Opposing roles for sMAdCAM and IL‐15 in COVID‐19 associated cellular immune pathology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3covbcr0621-300r
Abstract: Immune cell dysregulation and lymphopenia characterize COVID‐19 pathology in moderate to severe disease. While underlying inflammatory factors have been extensively studied, homeostatic and mucosal migratory signatures remain largely unexplored as causative factors. In this study,… read more here.
Keywords: roles smadcam; opposing roles; smadcam covid; pathology ... See more keywords
Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.033
Abstract: The transforming growth factor β (TGF-β) superfamily participates in tumour proliferation, apoptosis, differentiation, migration, invasion, immune evasion and extracellular matrix remodelling. Genetic deficiency in distinct components of TGF-β and BMP-induced signalling pathways or their excessive… read more here.
Keywords: bmp pathways; bmp; tgf bmp; opposing roles ... See more keywords
Opposing roles of C/EBPα and eEF1A1 in Sp1-regulated miR-122 transcription
Sign Up to like & getrecommendations! Published in 2019 at "RNA Biology"
DOI: 10.1080/15476286.2019.1673656
Abstract: ABSTRACT We previously showed that miR-122 was frequently downregulated in hepatocellular carcinoma (HCC) and C/EBPα transactivated miR-122 expression. In this study, we found that Sp1 bound to the miR-122 promoter at two different sites. Interestingly,… read more here.
Keywords: transcription; 122 transcription; opposing roles; mir 122 ... See more keywords
Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-06-0467
Abstract: Different forms of nuclear envelope–spanning LINC complexes have opposing roles in the transcription-independent control of the small GTPase RhoA. Competition between LINC complexes in the nuclear envelope may therefore dictate the outcome of signaling to… read more here.
Keywords: linc complexes; opposing roles; gtpase rhoa; small gtpase ... See more keywords
Abstract 1504: Opposing roles of FoxM1 and the hepatic specification genes FoxA1/A2 dictate differentiation state of liver cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1504
Abstract: The pro-proliferation transcription factor FoxM1 is over-expressed mainly in high-grade cancers. However, the significance of its over-expression in cancers, including poorly differentiated hepatocellular carcinoma (HCC), is not known. Here we provide evidence for a causal… read more here.
Keywords: opposing roles; differentiation state; differentiation; genes foxa1 ... See more keywords
Abstract 937: Opposing roles of SPOP mutations in human prostate and endometrial cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-937
Abstract: Recurrent mutations in the gene encoding the Speckle Type POZ Protein, SPOP, the substrate-binding components of E3-ubiquitin ligase, have been identified as common alterations in prostate cancer (PCa) and endometrial cancer (EC). SPOP mutations are… read more here.
Keywords: spop mutations; opposing roles; pca; spop mutated ... See more keywords
Opposing Roles of Dendritic Cell Subsets in Experimental GN.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017030270
Abstract: Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. However, previous studies of DC function used markers, such as… read more here.
Keywords: dcs; opposing roles; subsets experimental; cell subsets ... See more keywords
Opposing Roles of FoxA1 and FoxA3 in Intrahepatic Cholangiocarcinoma Progression
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21051796
Abstract: Cholangiocarcinoma (CCA), a malignancy of biliary epithelium, is related to liver stem cell deregulation. FoxAs are a group of transcription factors that play critical roles in liver stem cell differentiation. In this study, the expression… read more here.
Keywords: opposing roles; foxa1 foxa3; cholangiocarcinoma; roles foxa1 ... See more keywords