Implication of OPRM1 A118G Polymorphism in Opioids Addicts in Pakistan: In vitro and In silico Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1123-1
Abstract: Single nucleotide polymorphism in OPRM1 gene is associated with hedonic and reinforcing consequences of opioids. Risk and protective alleles may vary in different populations. One hundred healthy controls and 100 opioids (predominantly heroin) addicts from… read more here.
Keywords: oprm1 a118g; silico analysis; polymorphism; implication oprm1 ... See more keywords
OPRM1 A118G and serum β-endorphin interact with sex and digit ratio (2D:4D) to influence risk and course of alcohol dependence
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2018.09.002
Abstract: Activation of mesolimbic mu-opioid receptors by their endogenous ligand, β-endorphin, can mediate the rewarding effects of alcohol. However, there is conflicting evidence on the relationship between the mu-opioid receptor (OPRM1) A118G single nucleotide polymorphism (SNP)… read more here.
Keywords: risk; sex; oprm1 a118g; alcohol dependence ... See more keywords
Genetic variation in the behavioral effects of buprenorphine in female mice derived from a murine model of the OPRM1 A118G polymorphism
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.02.005
Abstract: &NA; Pharmacogenetic studies have identified the non‐synonymous single nucleotide polymorphism (A118G) in the human mu opioid receptor (MOR) gene (OPRM1) as a critical genetic variant capable of altering the efficacy of opioid therapeutics. To date… read more here.
Keywords: behavioral effects; effects buprenorphine; mice; oprm1 a118g ... See more keywords
The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-017-0002-8
Abstract: The endogenous opioid system may be involved in the development and maintenance of alcohol use disorder (AUD) and is a target for existing AUD pharmacotherapies. A functional polymorphism of the mu-opioid receptor gene (OPRM1 A118G,… read more here.
Keywords: genotype; sensitivity; oprm1 a118g; consumption ... See more keywords
Significance of CYP3A4∗1G and OPRM1 A118G Polymorphisms in Postoperative Sufentanil Analgesia in Women of Different Ethnicities
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/9833591
Abstract: Objective To investigate the association between CYP3A4∗1G and OPRM1A118G gene polymorphisms and postoperative analgesia with sufentanil in women of Zhuang ethnicity from western Guangxi, China. Methods Forty-eight Chinese Zhuang women who underwent elective myomectomy under… read more here.
Keywords: cyp3a4 oprm1; sufentanil; zhuang; oprm1 a118g ... See more keywords
The Influence of OPRM1 A118G Polymorphism on the Dosage of Morphine in Patients with Advanced Liver Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP"
DOI: 10.29271/jcpsp.2021.11.1375
Abstract: This study was conducted to investigate the influence of μ-opioid receptor gene (OPRM1) A118G polymorphism on dosage of morphine in advanced liver cancer patients. Seventy patients with advanced liver cancer at Changyi People's Hospital, Shandong… read more here.
Keywords: morphine; dosage morphine; oprm1 a118g; dosage ... See more keywords