Dysregulated expression of the alternatively spliced variant mRNAs of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of male human heroin abusers and heroin self-administering male rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24640
Abstract: Heroin, a mu agonist, acts through the mu opioid receptor. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, creating an array of splice variants that are conserved from rodent to humans. Increasing evidence… read more here.
Keywords: opioid receptor; heroin abusers; heroin; oprm1 splice ... See more keywords