Transcriptome profiling of zebrafish optic fissure fusion
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-38379-5
Abstract: Incomplete fusion of the optic fissure leads to ocular coloboma, a congenital eye defect that affects up to 7.5 per 10,000 births and accounts for up to 10 percent of childhood blindness. The molecular and… read more here.
Keywords: optic fissure; fissure; expression; zebrafish optic ... See more keywords
Nf2 fine-tunes proliferation and tissue alignment during closure of the optic fissure in the embryonic mouse eye.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa228
Abstract: Uveal coloboma represents one of the most common congenital ocular malformations accounting for up to 10% of childhood blindness (1~ in 5,000 live birth). Coloboma originates from defective fusion of the optic fissure (OF), a… read more here.
Keywords: closure; optic fissure; coloboma; fissure ... See more keywords
Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.43877
Abstract: Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure… read more here.
Keywords: chick; fissure closure; fusion; optic fissure ... See more keywords