Surveillance magnetic resonance imaging for isolated optic pathway gliomas: is gadolinium necessary?
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Radiology"
DOI: 10.1007/s00247-018-4154-4
Abstract: BackgroundPediatric optic pathway gliomas are typically indolent but have a variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced MRI examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast… read more here.
Keywords: contrast; contrast enhanced; pathway gliomas; optic pathway ... See more keywords
Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases
Sign Up to like & getrecommendations! Published in 2018 at "Child's Nervous System"
DOI: 10.1007/s00381-018-3739-4
Abstract: BackgroundDespite appropriate therapeutic interventions, progressive optic pathway glioma (OPG) in children may result in loss of vision and other neurologic morbidities. Molecularly targeted therapy against the MAP kinase pathway holds promise in improving outcomes while… read more here.
Keywords: inhibitor; response; pathway glioma; pathway ... See more keywords
Natural history of optic pathway gliomas in a cohort of unselected patients affected by Neurofibromatosis 1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2517-6
Abstract: Optic pathway glioma (OPG) represents the most common central nervous system tumor in children with Neurofibromatosis type-1 (NF1). Although overall survival is usually good, no clear prognostic factors have been identified so far. We assessed… read more here.
Keywords: cohort unselected; unselected patients; natural history; patients affected ... See more keywords
A rare case of sporadic malignant optic pathway glioma in a 71-yearold woman.
Sign Up to like & getrecommendations! Published in 2019 at "World neurosurgery"
DOI: 10.1016/j.wneu.2019.07.108
Abstract: BACKGROUND While optic pathway gliomas (OPGs) are a frequent finding in pediatric patients with neurofibromatosis type 1, sporadic malignant optic pathway gliomas (mOPGs) in adult patients are more rare with 72 cases described in the… read more here.
Keywords: sporadic malignant; treatment; case; malignant optic ... See more keywords
The utility of early brain MRI for patients with neurofibromatosis type 1 and optic pathway glioma: A long-term follow-up in a tertiary referral hospital.
Sign Up to like & getrecommendations! Published in 2022 at "Neuropediatrics"
DOI: 10.1055/a-1816-8746
Abstract: OBJECTIVE Screening studies have shown detection of optic pathway gliomas (OPGs) in 8-31% of children with neurofibromatosis type 1 (NF1). Many of those affected show prolonged indolent phases, but others develop vision disturbances even before… read more here.
Keywords: brain mri; mri; optic pathway; neurofibromatosis type ... See more keywords
Anterior optic pathway pathology in CNS demyelinating diseases
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac030
Abstract: Abstract The anterior optic pathway is one of the preferential sites of involvement in CNS inflammatory demyelinating diseases, such as multiple sclerosis and neuromyelitis optica, with optic neuritis being a common presenting symptom. What is… read more here.
Keywords: inflammation; optic pathway; age; pathology ... See more keywords
LGG-29. TREATMENT FOR RECURRENT OPTIC PATHWAY PILOCYTIC ASTROCYTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.411
Abstract: Abstract Chemotherapy after biopsy or partial resection of the tumor is widely accepted as first-line therapy for optic pathway pilocytic astrocytoma. However, there is no standard of care for recurred tumors. We investigated our cases… read more here.
Keywords: pathway pilocytic; pilocytic astrocytoma; recurrence; optic pathway ... See more keywords
Treatment of NF1-associated Optic Pathway/Hypothalamic Gliomas in Patients With Diencephalic Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pediatric hematology/oncology"
DOI: 10.1097/mph.0000000000002569
Abstract: Diencephalic syndrome is usually associated with tumors in the hypothalamic region, rarely occurring in patients with neurofibromatosis type 1 (NF1)-associated gliomas. We describe the clinical presentation and response to treatment in 3 patients with NF1… read more here.
Keywords: optic pathway; nf1 associated; pathway hypothalamic; gliomas ... See more keywords
The Potential Pathogenicity of Myelin Oligodendrocyte Glycoprotein Antibodies in the Optic Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Ophthalmology"
DOI: 10.1097/wno.0000000000001772
Abstract: Background: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an acquired inflammatory demyelinating disease with optic neuritis (ON) as the most frequent clinical symptom. The hallmark of the disease is the presence of autoantibodies against… read more here.
Keywords: optic pathway; mog igg; oligodendrocyte glycoprotein; myelin oligodendrocyte ... See more keywords
Endocrine Long-Term Follow-Up of Children with Neurofibromatosis Type 1 and Optic Pathway Glioma
Sign Up to like & getrecommendations! Published in 2017 at "Hormone Research in Paediatrics"
DOI: 10.1159/000458525
Abstract: Background/Aims: Children with optic pathway glioma (OPG) face sequelae related to tumour location and treatment modalities. We aimed to assess the prevalence of hypothalamic-pituitary dysfunctions in children with neurofibromatosis type 1 (NF1) and OPG who… read more here.
Keywords: pathway glioma; tumour location; children neurofibromatosis; neurofibromatosis type ... See more keywords
Teaching NeuroImage: Optic Pathway Involvement in Maple Syrup Urine Disease
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201290
Abstract: A 10-day-old neonate presented with vomiting and irritability. Diffusion-weighted imaging showed abnormal signal intensities, including characteristic involvement of the optic pathway (Figure, A and B). Maple syrup urine disease (MSUD) was suspected. Blood tests confirmed… read more here.
Keywords: maple syrup; optic pathway; involvement; syrup urine ... See more keywords